Cancer Causes & Control

, Volume 15, Issue 6, pp 571–580

Alcohol Drinking May Increase Risk of Breast Cancer in Men: A European Population-Based Case–Control Study

  • Pascal Guénel
  • Diane Cyr
  • Svend Sabroe
  • Elsebeth Lynge
  • Franco Merletti
  • Wolfgang Ahrens
  • Cornelia Baumgardt-Elms
  • François Ménégoz
  • Håkan Olsson
  • Stein Paulsen
  • Lorenzo Simonato
  • Gun Wingren
Article

DOI: 10.1023/B:CACO.0000036154.18162.43

Cite this article as:
Guénel, P., Cyr, D., Sabroe, S. et al. Cancer Causes Control (2004) 15: 571. doi:10.1023/B:CACO.0000036154.18162.43

Abstract

Objective: It has been estimated that alcohol drinking increases the risk of breast cancer in women by approximately 7% for each increment of 10 g alcohol per day. However, the few studies conducted on breast cancer among men have failed to detect an association with quantitative measures of alcohol drinking, even if the alcohol intake is generally higher in men than in women. On the other hand, increased risks of male breast cancer were inconsistently reported in alcoholics or patients with liver cirrhosis. We have investigated the role of alcohol drinking in male breast cancer using data collected in a population-based case–control study on seven rare cancers, conducted in Denmark, France, Germany, Italy, and Sweden.

Methods: The cases were 74 histologically verified male breast cancer patients aged 35–70 years. The controls (n = 1432) were selected from population registers, and frequency-matched to the cases by age group and geographic area. To check for consistency, a separate analysis was conducted using as controls the patients with a rare cancer other than male breast recruited simultaneously in the European study (n = 519 men).

Results: Based on population controls, the risk of developing breast cancer in men increased by 16%(95% CI: 7–26%) per 10 g alcohol /day (p < 0.001). An odds ratio of 5.89 (95% CI: 2.21-15.69) was observed for alcohol intake greater than 90 g per day, as compared with light consumers ( < 15 g per day). Similar associations were observed when other rare cancers patients were used as controls.

Conclusion: We found that the relative risk of breast cancer in men is comparable to that in women for alcohol intakes below 60 g per day. It continues to increase at high consumption levels not usually studied in women.

alcohol drinking breast neoplasms case–control studies male risk factors 

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Pascal Guénel
    • 1
    • 2
  • Diane Cyr
    • 1
  • Svend Sabroe
    • 3
  • Elsebeth Lynge
    • 4
  • Franco Merletti
    • 5
  • Wolfgang Ahrens
    • 6
  • Cornelia Baumgardt-Elms
    • 7
  • François Ménégoz
    • 8
  • Håkan Olsson
    • 9
  • Stein Paulsen
    • 10
  • Lorenzo Simonato
    • 11
  • Gun Wingren
    • 12
  1. 1.INSERM UnitéSaint-MauriceFrance
  2. 2.INSERM Unité 170Villejuif CedexFrance
  3. 3.University of AarhusDenmark
  4. 4.University of CopenhagenDenmark
  5. 5.Unit of Cancer Epidemiology, CERMS and Centre for Oncologic PreventionUniversity of TurinItaly
  6. 6.Bremen Institute for Prevention Research and Social MedicineUniversity of BremenGermany
  7. 7.Hamburg Cancer RegistryGermany
  8. 8.Isère Cancer RegistryGrenoble and ‘Réseau FRANCIM’-ToulouseFrance
  9. 9.University of LundSweden
  10. 10.Institute of PathologyAalborgDenmark
  11. 11.Department of Environmental Medicine and Public HealthUniversity of PadovaItaly
  12. 12.Division of Occupational and Environmental MedicineLinköping UniversitySweden

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