Journal of Inherited Metabolic Disease

, Volume 27, Issue 3, pp 305–317

After the genome—the phenome?

Authors

  • C. R. Scriver
    • Departments of Biology, Human Genetics, and PediatricsMcGill University, McGill University Health Center, A-721, Montreal Children's Hospital
Article

DOI: 10.1023/B:BOLI.0000031100.26546.6e

Cite this article as:
Scriver, C.R. J Inherit Metab Dis (2004) 27: 305. doi:10.1023/B:BOLI.0000031100.26546.6e

Abstract

Summary: What next? The Human Genome Project signifies complexity rather than simplification in the relationship between genotype and phenotype. Genotypes are embedded in genomes. Individuality in phenotypes is embedded in components of the phenome (transcriptome, metabolome, proteome, etc.). The phenome, its layers, and its nodes, links and networks, require elucidation; there is a need for a Human Phenome Project (Freimer and Sabatti 2003). Biology has largely been a reductive science in the recent past; integrative biology lies ahead. Clinician-scientists (including human biochemical geneticists) will be recognized as key participants in the ‘medical’ Phenome Project as it reveals components of individuality, and their contributions, in simple or combinatorial fashion, to Mendelian and complex traits; better ways to treat ‘genetic disease’ will be by-products of the project.

Although the Word is common to all, most men live as if each had a private wisdom of his own.

Herakleitos

Copyright information

© Kluwer Academic Publishers 2004