Biotechnology Letters

, Volume 26, Issue 14, pp 1125–1130

Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense

  • Dong Gun Lee
  • Yoonkyung Park
  • Mi-Ran Kim
  • Hyun Jun Jung
  • Young Bae Seu
  • Kyung-Soo Hahm
  • Eun-Rhan Woo
Article

DOI: 10.1023/B:BILE.0000035483.85790.f7

Cite this article as:
Lee, D.G., Park, Y., Kim, MR. et al. Biotechnology Letters (2004) 26: 1125. doi:10.1023/B:BILE.0000035483.85790.f7

Abstract

Four phenolic amides, dihydro-N-caffeoyltyramine (1), trans-N-feruloyloctopamine (2), trans-N-caffeoyltyramine (3), and cis-N-caffeoyltyramine (4), were isolated from an ethyl acetate extract of the root bark of Lycium chinense Miller. All had an anti-fungal effect; compounds 1-3 were potent at 5–10 μg ml−1 and were without hemolytic activity against human erythrocyte cells. Compound 4 was active at 40 μg ml−1. All four compounds impeded the dimorphic transition of pathogen, Candida albicans.

anti-fungal activity trans-N-caffeoyltyramine dihydro-N-caffeoyltyramine trans-N-feruloyloctopamine Lycium chinense Solanaceae 

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Dong Gun Lee
    • 1
  • Yoonkyung Park
    • 2
    • 3
  • Mi-Ran Kim
    • 2
    • 3
  • Hyun Jun Jung
    • 1
  • Young Bae Seu
    • 1
  • Kyung-Soo Hahm
    • 2
    • 3
  • Eun-Rhan Woo
    • 2
    • 3
    • 3
  1. 1.Department of MicrobiologyKyungpook National UniversityDaeguRepublic of Korea
  2. 2.Research Center for Proteineous MaterialsRepublic of Korea
  3. 3.College of PharmacyChosun UniversityGwangjuRepublic of Korea

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