Biotechnology Letters

, Volume 26, Issue 13, pp 1073–1076

Regioselective acylation of flavonoids catalyzed by immobilized Candida antarctica lipase under reduced pressure

  • Emilie Passicos
  • Xavier Santarelli
  • Denis Coulon
Article

DOI: 10.1023/B:BILE.0000032967.23282.15

Cite this article as:
Passicos, E., Santarelli, X. & Coulon, D. Biotechnology Letters (2004) 26: 1073. doi:10.1023/B:BILE.0000032967.23282.15

Abstract

A single-step acylation of rutin and naringin, catalyzed by immobilized Candida antarctica lipase B in 2-methyl-2-butanol, occurred preferentially on the primary hydroxyl group. Using palmitic methyl ester as acyl donor, the acylation rate of naringin was 10-fold higher than that of rutin. Under optimal conditions, i.e. a molar ratio acyl donor/naringin of 7:1 and 200 mbar, 92% naringin was acylated.

Candida antarctica lipaseflavonoid estermolar ratioreduced pressuretransesterification

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Emilie Passicos
    • 1
  • Xavier Santarelli
    • 1
  • Denis Coulon
    • 1
  1. 1.Ecole Supérieure de Technologie des Biomolécules de BordeauxUniversité Victor Segalen Bordeaux2Bordeaux cedexFrance