Behavior Genetics

, Volume 34, Issue 3, pp 319–324

Spatial Memory of Heterozygous Staggerer (Rora+/Rorasg) Versus Normal (Rora+/Rora+) Mice During Aging

  • J. Caston
  • C. Chianale
  • J. Mariani

DOI: 10.1023/B:BEGE.0000017875.78571.a6

Cite this article as:
Caston, J., Chianale, C. & Mariani, J. Behav Genet (2004) 34: 319. doi:10.1023/B:BEGE.0000017875.78571.a6


Heterozygous staggerer mice (Rora+/Rorasg) and control mice (Rora+/Rora+) of the same C57BL/6J strain background were tested in a spontaneous alternation task at 3 to 24 months old. The results demonstrated a decrement in long-term working memory as early as 6 months in Rora+/Rora+ mice and at 3 months in Rora+/Rorasg mice. Previous studies showed that in both cases, neuronal number in the cerebellar cortex was normal (Doulazmi et al. [1999]). This suggests that age-dependent decrease in long-term working memory would be due to fine structural or biochemical changes preceding neuronal death in the cerebellum. Such subtle changes would occur more precociously in Rora+/Rorasg than in Rora+/Rora+ mice. Also, short-term working memory was preserved in Rora+/Rora+ mice as old as 24 months, but was impaired in 6-month-old Rora+/Rorasg mice.

Agingspontaneous alternationspatial memorycerebellumstaggerer mutant mouse

Copyright information

© Plenum Publishing Corporation 2004

Authors and Affiliations

  • J. Caston
    • 1
  • C. Chianale
    • 2
  • J. Mariani
    • 3
  1. 1.UPRES EA 1780, Laboratoire de Neurobiologie de l'Apprentissage, Faculté des SciencesUniversité de RouenFrance
  2. 2.Institut Gustave RoussyVillejuifFrance
  3. 3.Laboratoire Développement et Vieillissement du Système Nerveux, UMR7102 Neurobiologie des Processus AdaptatifsCNRS et Université Pierre et Marie CurieParisFrance