Behavior Genetics

, Volume 34, Issue 3, pp 319–324

Spatial Memory of Heterozygous Staggerer (Rora+/Rorasg) Versus Normal (Rora+/Rora+) Mice During Aging


  • J. Caston
    • UPRES EA 1780, Laboratoire de Neurobiologie de l'Apprentissage, Faculté des SciencesUniversité de Rouen
  • C. Chianale
    • Institut Gustave Roussy
  • J. Mariani
    • Laboratoire Développement et Vieillissement du Système Nerveux, UMR7102 Neurobiologie des Processus AdaptatifsCNRS et Université Pierre et Marie Curie

DOI: 10.1023/B:BEGE.0000017875.78571.a6

Cite this article as:
Caston, J., Chianale, C. & Mariani, J. Behav Genet (2004) 34: 319. doi:10.1023/B:BEGE.0000017875.78571.a6


Heterozygous staggerer mice (Rora+/Rorasg) and control mice (Rora+/Rora+) of the same C57BL/6J strain background were tested in a spontaneous alternation task at 3 to 24 months old. The results demonstrated a decrement in long-term working memory as early as 6 months in Rora+/Rora+ mice and at 3 months in Rora+/Rorasg mice. Previous studies showed that in both cases, neuronal number in the cerebellar cortex was normal (Doulazmi et al. [1999]). This suggests that age-dependent decrease in long-term working memory would be due to fine structural or biochemical changes preceding neuronal death in the cerebellum. Such subtle changes would occur more precociously in Rora+/Rorasg than in Rora+/Rora+ mice. Also, short-term working memory was preserved in Rora+/Rora+ mice as old as 24 months, but was impaired in 6-month-old Rora+/Rorasg mice.

Agingspontaneous alternationspatial memorycerebellumstaggerer mutant mouse

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© Plenum Publishing Corporation 2004