Induction of apoptosis by tumor cell-targeted toxins
- Cite this article as:
- Thorburn, A., Thorburn, J. & Frankel, A.E. Apoptosis (2004) 9: 19. doi:10.1023/B:APPT.0000012118.95548.88
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Targeted toxins are fusion proteins that combine a targeting molecule that selectively binds to and enters tumor cells with a protein toxin that kills the target cells. These molecules represent an exciting approach to develop effective cancer-specific therapeutics that have few side effects on normal tissues and numerous such toxins are in various stages of pre-clinical and clinical development to treat a wide variety of tumors. In this review, we discuss this strategy, describe ways that the toxins activate the apoptosis machinery and discuss future developments in this field.