, Volume 9, Issue 1, pp 19–25

Induction of apoptosis by tumor cell-targeted toxins


DOI: 10.1023/B:APPT.0000012118.95548.88

Cite this article as:
Thorburn, A., Thorburn, J. & Frankel, A.E. Apoptosis (2004) 9: 19. doi:10.1023/B:APPT.0000012118.95548.88


Targeted toxins are fusion proteins that combine a targeting molecule that selectively binds to and enters tumor cells with a protein toxin that kills the target cells. These molecules represent an exciting approach to develop effective cancer-specific therapeutics that have few side effects on normal tissues and numerous such toxins are in various stages of pre-clinical and clinical development to treat a wide variety of tumors. In this review, we discuss this strategy, describe ways that the toxins activate the apoptosis machinery and discuss future developments in this field.

apoptosis cancer treatment chemotherapy diphtheria toxin 

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  1. 1.Department of Cancer BiologyWake Forest University School of MedicineWinston-SalemUSA