, Volume 9, Issue 1, pp 5–18

TMS1/ASC: The cancer connection


DOI: 10.1023/B:APPT.0000012117.32430.0c

Cite this article as:
McConnell, B.B. & Vertino, P.M. Apoptosis (2004) 9: 5. doi:10.1023/B:APPT.0000012117.32430.0c


TMS1/ASC is a bipartite protein comprising two protein-protein interaction domains, a pyrin domain (PYD) and a caspase recruitment domain (CARD). Proteins containing these domains play pivotal roles in regulating apoptosis and immune response pathways, and mutations in a number of PYD- and CARD-containing proteins have been linked to autoinflammatory diseases and cancer. Indeed, one of the ways in which TMS1/ASC was identified was as a target of methylation-mediated silencing in breast cancer cells. This review discusses the mounting evidence supporting a correlation between the silencing of TMS1/ASC expression and cancer. In addition, it addresses the reported functions of TMS1/ASC that include apoptosis, activation of inflammatory caspases and regulation of NF-kappa B, and discusses the potential ways in which loss of TMS1/ASC contributes to carcinogenesis.

ASCapoptosiscancerCARDcaspaseNF-κBpyrin domainTMS1

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  1. 1.Department of Radiation Oncology and Winship Cancer InstituteEmory University School of MedicineAtlantaUSA