We report basic results from new numerical simulations of passive scalar mixing at Schmidt numbers (Sc) of the order of 1000 in isotropic turbulence. The required high grid-resolution is made possible by simulating turbulence at very low Reynolds numbers, which nevertheless possesses universality in dissipative scales of motion. The results obtained are qualitatively consistent with those based on another study (Yeung et al., Phys. Fluids14 (2002) 4178-4191) with a less extended Schmidt number range and a higher Reynolds number. In the stationary state maintained by a uniform mean scalar gradient, the scalar variance increases slightly with Sc but scalar dissipation is nearly constant. As the Schmidt number increases, there is an increasing trend towards k−1 scaling predicted by Batchelor (Batchelor, J. Fluid Mech.5 (1959) 113-133) for the viscous-convective range of the scalar spectrum; the scalar gradient skewness approaches zero; and the intermittency measured by the scalar gradient flatness approaches its asymptotic state. However, the value of Sc needed for the asymptotic behavior to emerge appears to increase with decreasing Reynolds number of the turbulence. In the viscous-diffusive range, the scalar spectrum is in better agreement with Kraichnan's (Kraichnan., Phys. Fluids11 (1968) 945-953) result than with Batchelor's.