, Volume 7, Issue 1, pp 17–28

Eph Receptor Tyrosine Kinases in Angiogenesis: From Development to Disease

  • Dana M. Brantley-Sieders
  • Jin Chen

DOI: 10.1023/B:AGEN.0000037340.33788.87

Cite this article as:
Brantley-Sieders, D.M. & Chen, J. Angiogenesis (2004) 7: 17. doi:10.1023/B:AGEN.0000037340.33788.87


Angiogenesis, the process by which new blood vessels sprout and branch from existing vasculature, is crucial for vascular remodeling during embryogenesis and in normal tissue homeostasis, such as in the female reproductive tract. Angiogenesis can also contribute to the pathogenesis of diseases such as cancer and retinopathy. The Eph family of receptor tyrosine kinases and their ligands, called ephrins, has emerged as critical regulators of vascular remodeling in the embryo. More recently, these molecules have been associated with post-natal angiogenic remodeling and tumor neovascularization. This review provides an overview of recent advances in our understanding of Eph/ephrins in angiogenesis, with an emphasis on development and disease, and the potential for targeting these molecules in anti-angiogenic therapy.


Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Dana M. Brantley-Sieders
    • 1
    • 1
  • Jin Chen
    • 1
    • 2
    • 3
    • 4
  1. 1.Department of MedicineDivision of Rhematology and ImmunologyUSA
  2. 2.Department of Cancer BiologyUSA
  3. 3.Department of Cell and Developmental BiologyUSA
  4. 4.Vanderbilt University School of MedicineNashvilleUSA