Neurochemical Research

, Volume 22, Issue 4, pp 523–527

Membrane Phospholipid Alterations In Alzheimer's Disease: Deficiency of Ethanolamine Plasmalogens

  • Akhlaq A. Farooqui
  • Stanley I. Rapoport
  • Lloyd A. Horrocks
Article

DOI: 10.1023/A:1027380331807

Cite this article as:
Farooqui, A.A., Rapoport, S.I. & Horrocks, L.A. Neurochem Res (1997) 22: 523. doi:10.1023/A:1027380331807

Abstract

The ethanolamine plasmalogens are decreased whereas serine glycerophospholipids are significantly increased in plasma membrane phospholipid in affected regions of brain in Alzheimer's disease. This may be due to stimulation of Ca2+-independent plasmalogen-selective phospholipase A2, which was recently discovered in brain. This phospholipase A2 differs from other Ca2+-independent phospholipases A2 in response to ATP and various inhibitors. It may be responsible for excess release of arachidonic acid and accumulation of prostaglandins and lipid peroxides in AD. Accumulation of the above lipid metabolites due to abnormal receptor function and signal transduction may contribute to neurodegeneration in AD.

Plasmalogens phospholipase A2 lipid peroxidation plasma membrane signal transduction neurodegradation Alzheimer's disease 

Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • Akhlaq A. Farooqui
    • 1
  • Stanley I. Rapoport
    • 2
  • Lloyd A. Horrocks
    • 1
  1. 1.Department of Medical BiochemistryThe Ohio State UniversityColumbus
  2. 2.Laboratory of NeurosciencesNational Institute on AgingBethesda