Journal of Mammalian Evolution

, Volume 4, Issue 2, pp 77–86

Are Guinea Pigs Rodents? The Importance of Adequate Models in Molecular Phylogenetics

  • Jack Sullivan
  • David L. Swofford
Article

DOI: 10.1023/A:1027314112438

Cite this article as:
Sullivan, J. & Swofford, D.L. Journal of Mammalian Evolution (1997) 4: 77. doi:10.1023/A:1027314112438

Abstract

The monophyly of Rodentia has repeatedly been challenged based on several studies of molecular sequence data. Most recently, D'Erchia et al. (1996) analyzed complete mtDNA sequences of 16 mammals and concluded that rodents are not monophyletic. We have reanalyzed these data using maximum-likelihood methods. We use two methods to test for significance of differences among alternative topologies and show that (1) models that incorporate variation in evolutionary rates across sites fit the data dramatically better than models used in the original analyses, (2) the mtDNA data fail to refute rodent monophyly, and (3) the original interpretation of strong support for nonmonophyly results from systematic error associated with an oversimplified model of sequence evolution. These analyses illustrate the importance of incorporating recent theoretical advances into molecular phylogenetic analyses, especially when results of these analyses conflict with classical hypotheses of relationships.

inconsistencymaximum likelihoodmolecular systematicsrodentsrate heterogeneity

Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • Jack Sullivan
    • 1
    • 1
  • David L. Swofford
    • 1
  1. 1.Laboratory of Molecular Systematics, MSCSmithsonian Institution, MRC-534