Digestive Diseases and Sciences

, Volume 44, Issue 12, pp 2538–2541

Mortality and Causes of Death in Celiac Disease in a Mediterranean Area

  • Authors
  • Mario Cottone
  • Anna Termini
  • Lorenzo Oliva
  • Antonino Magliocco
  • Ciro Marrone
  • Ambrogio Orlando
  • Filippo Pinzone
  • Roberto Di Mitri
  • Matteo Rosselli
  • Aroldo Rizzo
  • Luigi Pagliaro

DOI: 10.1023/A:1026655609906

Cite this article as:
Cottone, M., Termini, A., Oliva, L. et al. Dig Dis Sci (1999) 44: 2538. doi:10.1023/A:1026655609906


No data on mortality in celiac disease arecurrently available in southern Europe. Our aim was toevaluate mortality and the cause of death in adultceliac disease in a Mediterranean area. In all, 228adults with celiac disease were histologicallydiagnosed in our department from 1980 to 1997. Fullinformation on their state of health was obtained in 216of 228 patients. A tabulation of patient-years at risk was constructed in terms of age at diagnosisand the interval from diagnosis. Standardized mortalityratio was calculated by dividing the number of observeddeaths by the number of expected deaths. Twelve deaths were observed, whereas 3.12 deaths wereexpected (SMR = 3.8; 95% CI 2-7). The increasedmortality was mainly observed within four years fromdiagnosis (8 observed; 1.4 expected) (SMR = 5.8; 95% CI 2.5-11.5). Twelve tumors were observed (sixlymphomas). In conclusion, mortality from adult celiacdisease in our geographical area is increased comparedwith the general population, and this increased risk seems due to non-Hodgkin'slymphoma.


Copyright information

© Plenum Publishing Corporation 1999