Digestive Diseases and Sciences

, Volume 44, Issue 10, pp 2003-2007

First online:

Liver Transplantation in Patients with Chronic Hepatitis C and Alcoholism

  • Sanjay Dhar
  • , Louay Omran
  • , Bruce R. Bacon
  • , Harvey Solomon
  • , Adrian M. Di Bisceglie

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We evaluated the contribution of alcohol abuseto liver failure among patients undergoing livertransplantation by reviewing their records for alcoholconsumption, hepatitis serology, and outcome. Anti-HCV was present in the serum of 42 patients (39%),while 35 had consumed more than 80 g/day of alcohol forat least 10 years, allowing patients to be divided intofour groups: group I, hepatitis C alone (N = 31); groupII, alcoholic liver disease alone (N = 24); group III,both hepatitis C and alcoholism (N = 11); and group IV,liver failure due to other causes (N = 41). Patientswere followed for a mean of 29 months after transplantation (range0-66). Twenty-eight (26%) died during follow up, while11 (10%) required retransplantation. There were no othersignificant differences in patient or graft survival among patients in the four groups. Patientswith both alcoholism and chronic hepatitis C comprise alarge proportion of those undergoing livertransplantation and appear to do as well as those withother causes of liver failure, at least in the shortterm.