, Volume 44, Issue 8, pp 1710-1715

Lansoprazole Decreases Peripheral Blood Monocytes and Intercellular Adhesion Molecule-1-Positive Mononuclear Cells

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We examined the effects of lansoprazole, aproton-pump inhibitor, on peripheral blood mononuclearcells in healthy subjects in comparison with ranitidine.Ten healthy volunteers were randomly divided into two groups and given either lansoprazole (30 mgdaily for 2 days) or ranitidine (150 mg daily for 21days). Peripheral blood was collected before and 7, 14,and 21 days after the start of treatment. Mononuclear cells were isolated by densitometriccentrifugation and were examined for adhesion molecules(ICAM-1, VLA4, SLex), membrane markers of themonocyte/macrophage series, and lymphocyte phenotypes.The number of cells expressing adhesion molecules, thenumber of monocytes/macrophages, and lymphocytephenotypes were the same in Helicobacter pylori-positiveand-negative subjects. The number of cells expressing ICAM-1 was significantly decreased seven daysafter the start of lansoprazole treatment, and thischange persisted until day 14, while ranitidine had noeffect. The number of monocytes (identified by Leu-M3 positivity) was decreased seven days after thestart of treatment in both groups, but predominantly inthe lansoprazole group. No other changes were observedon administration of either drug. These results suggest that short-term treatment withlansoprazole causes persistent inhibition ofinflammatory responses irrespective of the presence ofH. pylori infection. This effect may indicate a possiblenew mechanism of action of proton-pump inhibitors other thaninhibition of acid secretion.