Behavior Genetics

, Volume 30, Issue 4, pp 285–293

Habituation of Activity in an Open Field: A Survey of Inbred Strains and F1 Hybrids

  • Valerie J. Bolivar
  • Barbara J. Caldarone
  • Andrew A. Reilly
  • Lorraine Flaherty
Article

DOI: 10.1023/A:1026545316455

Cite this article as:
Bolivar, V.J., Caldarone, B.J., Reilly, A.A. et al. Behav Genet (2000) 30: 285. doi:10.1023/A:1026545316455

Abstract

To determine if there is genetic variability in habituation of activity in an open field, we examined a number of inbred strains and F1 hybrids. Using 5-min exposures to a dark open field, we measured changes in exploratory behavior over 3 consecutive days in 129S3/SvImJ, A/J, BALB/ cByJ, C3H/HeJ, C57BL/6J, CBA/J, DBA/2J, FVB/NJ, (B6 × 129)F1/J, and (B6 × C3H) F1/J male and female mice. Strain differences in open-field activity and in habituation were evident. Some of the strain differences were further modified by sex. The strains and F1's could be separated into groups that increased, decreased, or did not modify their activities across testing sessions. In a second study, the effects of altering the floor surface on habituation were examined in male 129S3/SvImJ, C57BL/6J, DBA/2J, and (B6 × 129)F1/J mice. When the floor was altered after 3 consecutive days of habituation, increased activity levels were evident. There were strain differences in the responsiveness to the changes in the floor. These results confirm a genetic role in intersession habituation to an open field.

Inbred strainshabituationopen-field activity

Copyright information

© Plenum Publishing Corporation 2000

Authors and Affiliations

  • Valerie J. Bolivar
    • 1
    • 2
  • Barbara J. Caldarone
    • 1
    • 2
    • 3
  • Andrew A. Reilly
    • 4
    • 5
  • Lorraine Flaherty
    • 1
    • 6
  1. 1.Genomics Institute, Wadsworth CenterAlbany
  2. 2.Department of Biomedical SciencesUniversity at AlbanyAlbany
  3. 3.Department of PsychologyUniversity at AlbanyAlbany
  4. 4.Laboratory of Structural Pathology, Wadsworth CenterAlbany
  5. 5.Department of Biometry and StatisticsUniversity at AlbanyAlbanyNew York
  6. 6.Department of Biomedical SciencesUniversity at AlbanyAlbany