Journal of Mammary Gland Biology and Neoplasia

, Volume 5, Issue 2, pp 227–241

An Atlas of Mouse Mammary Gland Development

  • Monica M. Richert
  • Kathryn L. Schwertfeger
  • John W. Ryder
  • Steven M. Anderson
Article

DOI: 10.1023/A:1026499523505

Cite this article as:
Richert, M.M., Schwertfeger, K.L., Ryder, J.W. et al. J Mammary Gland Biol Neoplasia (2000) 5: 227. doi:10.1023/A:1026499523505

Abstract

The mouse mammary gland is a complex tissue, which is continually undergoing changes in structure and function. Embryonically, the gland begins with invasion of the underlying fat pad by a rudimentary ductal structure. Postnatal growth occurs in two phases: ductal growth and early alveolar development during estrous cycles, and cycles of proliferation, differentiation, and death that occur with each pregnancy, lactation, and involution. The variety of epithelial structures and stromal changes throughout the life of a mammary gland makes it a challenge to study. The purpose of this histological review is to give a brief representation of the morphological changes that occur throughout the cycle of mouse mammary gland development so that developmental changes observed in mouse models of mammary development can be appreciated.

mammary glandmouseductalveoliatlas

Copyright information

© Plenum Publishing Corporation 2000

Authors and Affiliations

  • Monica M. Richert
    • 1
  • Kathryn L. Schwertfeger
    • 2
  • John W. Ryder
    • 3
  • Steven M. Anderson
    • 3
    • 2
  1. 1.Department of PathologyUniversity of Colorado Health Sciences CenterDenver
  2. 2.Program in Molecular BiologyUniversity of Colorado Health Sciences CenterDenver
  3. 3.Department of PathologyUniversity of Colorado Health Sciences CenterDenver