, Volume 104, Issue 3, pp 231–233

The present status of the ‘carrier hypothesis’ for chemosensory recognition of genetic individuality

  • Prim B. Singh

DOI: 10.1023/A:1026475118901

Cite this article as:
Singh, P.B. Genetica (1998) 104: 231. doi:10.1023/A:1026475118901


The hypothesis that soluble MHC Class I molecules could act as the vector which transports MHC‐specific odours from the blood into the urine was put forward some ten years ago (Singh, Brown Roser, 1987). Here, I summarise new evidence in favour of the hypothesis.

‘We propose that the ability of MHC Class I molecules to associate in a selective way with other small molecules could also be the mechanism by which a unique mixture of volatile, endogenous metabolites is transported by [soluble] class I MHC glycoproteins from the blood into the urine’ (Singh, Brown Roser, 1987).

Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • Prim B. Singh
    • 1
  1. 1.Department of Development and GeneticsThe Babraham Institute, BabrahamCambridgeUK

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