The present status of the ‘carrier hypothesis’ for chemosensory recognition of genetic individuality
- Cite this article as:
- Singh, P.B. Genetica (1998) 104: 231. doi:10.1023/A:1026475118901
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The hypothesis that soluble MHC Class I molecules could act as the vector which transports MHC‐specific odours from the blood into the urine was put forward some ten years ago (Singh, Brown Roser, 1987). Here, I summarise new evidence in favour of the hypothesis.
‘We propose that the ability of MHC Class I molecules to associate in a selective way with other small molecules could also be the mechanism by which a unique mixture of volatile, endogenous metabolites is transported by [soluble] class I MHC glycoproteins from the blood into the urine’ (Singh, Brown Roser, 1987).