Journal of Mammary Gland Biology and Neoplasia

, Volume 2, Issue 1, pp 49-57

First online:

Early Mammary Development: Growth Hormone and IGF-1

  • David L. KleinbergAffiliated withDepartment of Medicine, New York University Medical Center, and Department of Veterans Affairs Medical Center

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The first step in pubertal mammary development is the appearance of terminal end buds arising from pleuropotent stem cells present in the immature ductal tree of the prepubertal animal. Work from this laboratory indicates that growth hormone is the pituitary hormone responsible for terminal end bud development. Growth hormone likely acts through the production of IGF-1.3 This minireview focuses on the hormonal control of early mammary development with special emphasis on the roles of growth hormone and IGF-1.

Pleuropotent stem cells pubertal mammary development terminal end bud lactogenesis