Early Mammary Development: Growth Hormone and IGF-1
- David L. Kleinberg
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The first step in pubertal mammary development is the appearance of terminal end buds arising from pleuropotent stem cells present in the immature ductal tree of the prepubertal animal. Work from this laboratory indicates that growth hormone is the pituitary hormone responsible for terminal end bud development. Growth hormone likely acts through the production of IGF-1.3 This minireview focuses on the hormonal control of early mammary development with special emphasis on the roles of growth hormone and IGF-1.
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About this Article
- Early Mammary Development: Growth Hormone and IGF-1
Journal of Mammary Gland Biology and Neoplasia
Volume 2, Issue 1 , pp 49-57
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers-Plenum Publishers
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- Pleuropotent stem cells
- pubertal mammary development
- terminal end bud
- Industry Sectors
- Author Affiliations
- 1. Department of Medicine, New York University Medical Center, and Department of Veterans Affairs Medical Center, New York, New York, 10016