Early Mammary Development: Growth Hormone and IGF-1
- David L. Kleinberg
- … show all 1 hide
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
The first step in pubertal mammary development is the appearance of terminal end buds arising from pleuropotent stem cells present in the immature ductal tree of the prepubertal animal. Work from this laboratory indicates that growth hormone is the pituitary hormone responsible for terminal end bud development. Growth hormone likely acts through the production of IGF-1.3 This minireview focuses on the hormonal control of early mammary development with special emphasis on the roles of growth hormone and IGF-1.
C. W. Daniel and G. B. Silberstein (1987). Postnatal development of the rodent mammary gland. In M. C. Neville, and C. W. Daniel (eds.), The Mammary Gland: Development, Regulation, and Function, Plenum Press, New York, pp. 1–36.
I. H. Russo, J. Medado, and J. Russo (1989). Endocrine influences on the mammary gland. In T. C. Jones, U. Mohr, and R. D. Hunt (eds.), Integument and Mammary Glands, Springer-Verlag, Berlin, pp. 252–265.
J. Russo and I. H. Russo (1978). DNA-labelling index and structure of the mammary gland as determinants of its susceptibility to carcinogenesis. J. Natl. Cancer Inst. 61:1451.
R. P. Reece, C. W. Turner, and R. T. Hill (1936). Mammary gland development in the hypophysectomized albino rat. Proc. Soc. Exp. Biol. Med. 34:204–217.
W. U. Gardner and A. White (1941). Mammary growth in hypophysectomized male mice receiving estrogen prolactin. Proc. Soc. Exp. Biol. Med. 48:590–592.
A. A. Lewis, E. T. Gomez, and C. W. Turner (1942). Mammary gland development with mammogen I in the castrated and the hypophysectomized rat. Endocrinology 30:37–47.
A. E. Wilhelmi (1995). Comparative biochemistry of growth hormone from ox, pig, horse, and sheep pituitaries. In R. W. Smith, O. H. Gaebler, and C. N. H. Long (eds.), Henry Ford Hospital International Symposium on the Hypophyseal Growth Hormone: Nature and Actions, McGraw Hill, New York, pp. 59–69.
M. S. Raben (1959). Human growth hormone. Rec. Prog. Horm. Res. 15:71–114.
W. R. Lyons, R. E. Johnson, R. D. Cole et al. (1959). Mammary growth and lactation in male rats. In R. W. Smith, O. H. Gaebler, and C. N. H. Long (eds.), The Hypophyseal Growth Hormone, Nature and Actions, McGraw Hill, New York, pp. 461–472.
W. R. Lyons, C. H. Li, and R. E. Johnson (1958). The hormonal control of mammary growth and lactation. Rec. Prog. Horm. Res. 14:219–248.
W. R. Lyons (1993). Hormonal synergism in mammary growth. Proc. Royal Soc. (London) 149:303–325.
S. Nandi (1958). Endocrine control of mammary-gland development and function in the C3 11/HE Crgl mouse. J. Natl. Cancer Inst. 21(6):1039–1062.
D. L. Kleinberg, W. Niemann, E. Flamm, P. Cooper, G. Babitsky, and Q. Valensi (1985). Primate mammary development: Effects of hypophysectomy, prolactin inhibition and growth hormone administration. J. Clin. Invest. 75:1943–1950.
W. L. J. Lowe (1991). Biological actions of insulin-like growth factors. In D. LeRoith (eds.), Insulin-Like Growth Factors: Molecular and Cellular Aspects (Vol. 3), CRC Press, Boca Raton, pp. 49–86.
D. L. Kleinberg, W. F. Ruan, V. Catanese, C. B. Newman, and M. Feldman (1990). Non-lactogenic effects of growth hormone on growth and insulin-like growth factor-I messenger ribonucleic acid of rat mammary gland. Endocrinology 126:3274–3276.
M. Feldman, W. Ruan, B. C. Cunningham, J. A. Wells, and D. L. Kleinberg (1993). Evidence that the growth hormone receptor mediates differentiation and development of the mammary gland. Endocrinology 133:1602–1608.
W. Ruan, C. B. Newman, and D. L. Kleinberg (1992). Intact and aminoterminally shortened forms of insulin-like growth factor 1 induce mammary gland differentiation and development. Proc. Natl. Acad. Sci. U.S.A. 89:10872–10876.
W. Ruan, V. Catanese, R. Wieczorek, M. Feldman, D. L. Kleinberg (1995). Estradiol enhances the stimulatory effect of insulin-like growth factor (IGF-1) on mammary development and growth hormone-induced IGF-1 messenger ribonucleic acid. Endocrinology 136:1296–1302.
R. P. C. Shiu and H. G. Friesen (1974). Properties of a prolactin receptor from the rabbit mammary gland. Biochem. J. 140:301–311.
R. P. C. Shiu and H. G. Friesen (1980). Mechanisms of action of prolactin in the control of mammary gland function. Ann. Rev. Physiol. 42:83–96.
D. R. Glimm, V. E. Baracos, and J. J. Kennelly (1990). Molecular evidence for the presence of growth hormone receptors in the bovine mammary gland. J. Endocrinol. 126:R5–R8.
D. W. Leung, S. A. Spencer, R. G. Hammonds, C. Collins, W. J. Henzel, R. Barnard, M. J. Waters, and W. J. Wood (1987). Growth hormone receptor and serum binding protein: purification, cloning, and expression. Nature 330:537–543.
S. D. Hauser, M. F. McGrath, R. J. Collier, and G. G. Krivi (1990). Cloning and in vivo expression of bovine growth hormone receptor mRNA. Mol. Cell Endocrinol. 72:187–200.
H. Jammes, P. Gaye, L. Belair, and J. Djiane (1991). Identification and characterization of growth hormone receptor mRNA in the mammary gland. Mol. Cell Endocrinol. 75:27–35.
D. T. Lincoln, M. J. Waters, W. Breipohl, F. Sinowatz, and P. E. Lobie (1990). Growth hormone receptors expression in the proliferating rat mammary gland. Acta Histochemica Suppl. Band XL:S47–S49.
M. Feldman, W. Ruan, and D. L. Kleinberg (1993). Measurement of growth hormone receptor in rat mammary gland. [Abstract] Program 75th Annual Meeting of the Endocrine Society 469A.
A. Nilsson, J. Isgaard, A. Lindahl, A. Dahlstrom, A. Skottner, and O. G. P. Isaksson (1986). Regulation by growth hormone of number of chondrocytes containing IGF-1 in rat growth plate. Science 233:571–574.
N. L. Schlecter, S. M. Russell, E. M. Spencer, and C. S. Nicell (1986). Evidence suggesting that the direct growth-promoting effect of growth hormone on cartilege in vivo is mediated by local production of somatunedin. Proc. Natl. Acad. Sci. U.S.A. 83:7932–7934.
L. J. Murphy, G. I. Bell, and H. G. Friesen (1987). Tissue distribution of insulin-like growth factor I and II messenger ribonucleic acid in the adult rat. Endocrinology 120:1279–1282.
C. Carlsson-Skwirut, M. Lake, M. Hartmanis, K. Hall, and V. R. Ara (1989). A comparison of the biological activity of the recombinant intact and truncated insulin-like growth factor 1 (IGF-1). Biochim. Biophys. Acta 1011:192–197.
M. F. McGrath, R. J. Collier, D. R. Clemmons, W. H. Busby, C. A. Sweeney, and G. G. Krivi (1991). The direct in vitro effect of insulin-like growth factors (IGFs) on normal bovine mammary cell proliferation and production of IGF binding proteins. Endocrinology 129:671–678.
D. L. Hadsell, N. M. Greenberg, J. M. Fligger, C. R. Baumrucker, C. R., and J. M. Rosen (1993). Targeted expression of des(1–3) human insulin-like growth factor 1 (IGF-1) in transgenic mice influences mammary gland development and IGF-binding protein expression. Endocrinology 136:(in press).
S. Neuenschwander, A. Schwartz, T. L. Wood, C. T. J. Roberts, L. Henninghausen, and D. LeRoith (1996). Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model. J. Clin. Invest. 97:2225–2232.
- Early Mammary Development: Growth Hormone and IGF-1
Journal of Mammary Gland Biology and Neoplasia
Volume 2, Issue 1 , pp 49-57
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers-Plenum Publishers
- Additional Links
- Pleuropotent stem cells
- pubertal mammary development
- terminal end bud
- Industry Sectors
- Author Affiliations
- 1. Department of Medicine, New York University Medical Center, and Department of Veterans Affairs Medical Center, New York, New York, 10016