Journal of Structural and Functional Genomics

, Volume 4, Issue 2, pp 115–120

Protein crystallization for genomics: throughput versus output

  • Naomi E. Chayen

DOI: 10.1023/A:1026174727482

Cite this article as:
Chayen, N.E. J Struct Func Genom (2003) 4: 115. doi:10.1023/A:1026174727482


Structural genomics involves many steps in order to reach from Gene to structure. This article focuses on the crystallization step in this chain of tasks. It is becoming increasingly evident that the current high throughput procedures for crystallising proteins do not always produce the expected output of high quality crystals required for structure determination by x-ray crystallography. This problem is discussed and suggestions for raising the output are presented.

GelsMicrobatchNucleationProtein crystallizationStructural GenomicsProteomics

Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Naomi E. Chayen
    • 1
  1. 1.Biological Structure and Function Section, Division of Biomedical Sciences, Faculty of MedicineImperial CollegeLondonUK