Article

Digestive Diseases and Sciences

, Volume 48, Issue 10, pp 2077-2082

A Randomized Trial of Yogurt for Prevention of Antibiotic-Associated Diarrhea

  • Ripudaman S. BeniwalAffiliated withDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine and Roudebush VA Medical Center Email author 
  • , Vincent C. ArenaAffiliated withDepartment of Biostatistics, Graduate School of Public Health, University of Pittsburgh
  • , Leno ThomasAffiliated withDepartment of Medicine, UPMC-McKeesport Hospital
  • , Sudhir NarlaAffiliated withDivision of Gastroenterology, Department of Medicine, UPMC-McKeesport Hospital
  • , Thomas F. ImperialeAffiliated withDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine and Roudebush VA Medical Center
  • , Rauf A. ChaudhryAffiliated withDepartment of Medicine, UPMC-McKeesport Hospital
  • , Usman A. AhmadAffiliated withDepartment of Medicine, UPMC-McKeesport Hospital

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Abstract

Antibiotic-associated diarrhea (AAD) is the most common adverse effect of antibiotic therapy. Our aim was to determine the effectiveness of a dietary supplement of yogurt for prevention of AAD. Two hundred two hospitalized patients receiving oral or intravenous antibiotics were randomized to receive or not receive a dietary yogurt supplement, consisting of 227 grams of commercial yogurt, and followed for 8 days. Mean age of the study group was 70 years and 43% were male. Compliance and 8-day follow-up were 85% and 91%, respectively. Patients receiving yogurt reported less frequent diarrhea (12% vs 24%; P = 0.04), and significantly less total diarrheal days (23 vs 60). The cumulative proportions of patients without diarrhea were significantly different (P = 0.02) between patients receiving and not receiving yogurt. For conclusion, dietary supplementation with yogurt is a simple, effective, and safe treatment that decreases the incidence and duration of AAD.

effectiveness yogurt dietary intervention biotherapeutics prophylaxis antibiotic-associated diarrhea