Digestive Diseases and Sciences

, Volume 48, Issue 10, pp 2077–2082

A Randomized Trial of Yogurt for Prevention of Antibiotic-Associated Diarrhea

Authors

    • Division of Gastroenterology and Hepatology, Department of MedicineIndiana University School of Medicine and Roudebush VA Medical Center
  • Vincent C. Arena
    • Department of Biostatistics, Graduate School of Public HealthUniversity of Pittsburgh
  • Leno Thomas
    • Department of MedicineUPMC-McKeesport Hospital
  • Sudhir Narla
    • Division of Gastroenterology, Department of MedicineUPMC-McKeesport Hospital
  • Thomas F. Imperiale
    • Division of Gastroenterology and Hepatology, Department of MedicineIndiana University School of Medicine and Roudebush VA Medical Center
  • Rauf A. Chaudhry
    • Department of MedicineUPMC-McKeesport Hospital
  • Usman A. Ahmad
    • Department of MedicineUPMC-McKeesport Hospital
Article

DOI: 10.1023/A:1026155328638

Cite this article as:
Beniwal, R.S., Arena, V.C., Thomas, L. et al. Dig Dis Sci (2003) 48: 2077. doi:10.1023/A:1026155328638

Abstract

Antibiotic-associated diarrhea (AAD) is the most common adverse effect of antibiotic therapy. Our aim was to determine the effectiveness of a dietary supplement of yogurt for prevention of AAD. Two hundred two hospitalized patients receiving oral or intravenous antibiotics were randomized to receive or not receive a dietary yogurt supplement, consisting of 227 grams of commercial yogurt, and followed for 8 days. Mean age of the study group was 70 years and 43% were male. Compliance and 8-day follow-up were 85% and 91%, respectively. Patients receiving yogurt reported less frequent diarrhea (12% vs 24%; P = 0.04), and significantly less total diarrheal days (23 vs 60). The cumulative proportions of patients without diarrhea were significantly different (P = 0.02) between patients receiving and not receiving yogurt. For conclusion, dietary supplementation with yogurt is a simple, effective, and safe treatment that decreases the incidence and duration of AAD.

effectivenessyogurtdietary interventionbiotherapeuticsprophylaxisantibiotic-associated diarrhea

Copyright information

© Plenum Publishing Corporation 2003