Digestive Diseases and Sciences

, Volume 48, Issue 10, pp 2077–2082

A Randomized Trial of Yogurt for Prevention of Antibiotic-Associated Diarrhea

  • Ripudaman S. Beniwal
  • Vincent C. Arena
  • Leno Thomas
  • Sudhir Narla
  • Thomas F. Imperiale
  • Rauf A. Chaudhry
  • Usman A. Ahmad
Article

DOI: 10.1023/A:1026155328638

Cite this article as:
Beniwal, R.S., Arena, V.C., Thomas, L. et al. Dig Dis Sci (2003) 48: 2077. doi:10.1023/A:1026155328638

Abstract

Antibiotic-associated diarrhea (AAD) is the most common adverse effect of antibiotic therapy. Our aim was to determine the effectiveness of a dietary supplement of yogurt for prevention of AAD. Two hundred two hospitalized patients receiving oral or intravenous antibiotics were randomized to receive or not receive a dietary yogurt supplement, consisting of 227 grams of commercial yogurt, and followed for 8 days. Mean age of the study group was 70 years and 43% were male. Compliance and 8-day follow-up were 85% and 91%, respectively. Patients receiving yogurt reported less frequent diarrhea (12% vs 24%; P = 0.04), and significantly less total diarrheal days (23 vs 60). The cumulative proportions of patients without diarrhea were significantly different (P = 0.02) between patients receiving and not receiving yogurt. For conclusion, dietary supplementation with yogurt is a simple, effective, and safe treatment that decreases the incidence and duration of AAD.

effectivenessyogurtdietary interventionbiotherapeuticsprophylaxisantibiotic-associated diarrhea

Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  • Ripudaman S. Beniwal
    • 1
  • Vincent C. Arena
    • 2
  • Leno Thomas
    • 3
  • Sudhir Narla
    • 4
  • Thomas F. Imperiale
    • 1
  • Rauf A. Chaudhry
    • 3
  • Usman A. Ahmad
    • 3
  1. 1.Division of Gastroenterology and Hepatology, Department of MedicineIndiana University School of Medicine and Roudebush VA Medical CenterIndianapolisIndiana
  2. 2.Department of Biostatistics, Graduate School of Public HealthUniversity of PittsburghPennsylvania
  3. 3.Department of MedicineUPMC-McKeesport HospitalPennsylvaniaUSA
  4. 4.Division of Gastroenterology, Department of MedicineUPMC-McKeesport HospitalPennsylvaniaUSA