Journal of Structural and Functional Genomics

, Volume 4, Issue 2, pp 167–177

From protein structure to biochemical function?

  • Roman A. Laskowski
  • James D. Watson
  • Janet M. Thornton
Article

DOI: 10.1023/A:1026127927612

Cite this article as:
Laskowski, R.A., Watson, J.D. & Thornton, J.M. J Struct Func Genom (2003) 4: 167. doi:10.1023/A:1026127927612

Abstract

Here we describe various methods currently under development aimed at identifying a protein’s function from its three-dimensional structure. We are combining a number of these methods to create a pipeline of applications, called ProFunc, which will take a given 3D structure, run all the applications on it and compile and summarise the results obtained. The aim is to provide a best guess as to the protein’s function from the evidence provided by the different methods. Here we present three examples, using structures solved by the Midwest Center for Structural Genomics consortium, illustrating the strengths and weaknesses of current approaches.

structure-based function prediction3D templates, active sitestructural genomics

Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Roman A. Laskowski
    • 1
  • James D. Watson
    • 1
  • Janet M. Thornton
    • 1
  1. 1.Wellcome Trust Genome Campus, HinxtonEuropean Bioinformatics InstituteCambridgeUK