Molecular and Cellular Biochemistry

, Volume 253, Issue 1, pp 207–215

Molecular mechanism of action of major Helicobacter pylori virulence factors

  • Suman Kumar Dhar
  • Rajesh K. Soni
  • Bimal K. Das
  • Gauranga Mukhopadhyay
Article

DOI: 10.1023/A:1026051530512

Cite this article as:
Dhar, S.K., Soni, R.K., Das, B.K. et al. Mol Cell Biochem (2003) 253: 207. doi:10.1023/A:1026051530512

Abstract

Although Helicobacter pylori infects 50% of the total human population, only a small fraction of the infected people suffer from severe diseases like peptic ulcers and gastric adenocarcinoma. H. pylori strains, host genotypes and environmental factors play important role in deciding the extent and severity of the gastroduodenal diseases. The bacteria has developed a unique set of virulence factors to survive in the extreme ecological niche of human stomach. Together these virulence factors make H. pylori one of the most successful human pathogenic bacteria colonizing more than half of the human population. Understanding the mechanism of action of the major H. pylori virulence factors will shed light into the molecular basis of its pathogenicity.

Helicobacter pylorivirulence factorstype IV secretion systemVacAPA

Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Suman Kumar Dhar
    • 1
  • Rajesh K. Soni
    • 1
  • Bimal K. Das
    • 2
  • Gauranga Mukhopadhyay
    • 1
  1. 1.Special Centre for Molecular MedicineJawaharlal Nehru UniversityNew DelhiIndia
  2. 2.Department of MicrobiologyAll India Institute of Medical SciencesNew DelhiIndia