Neuroscience and Behavioral Physiology

, Volume 33, Issue 9, pp 899–903

Anxiety Levels and Neurosteroid Synthesis in the Brains of Prenatally Stressed Male Rats

  • N. É. Ordyan
  • S. G. Pivina

DOI: 10.1023/A:1025952906715

Cite this article as:
Ordyan, N.É. & Pivina, S.G. Neurosci Behav Physiol (2003) 33: 899. doi:10.1023/A:1025952906715


This report presents studies of the effects of immobilization stress applied to pregnant female rats during the last third of pregnancy on anxiety levels and neurosteroid synthesis in brain structures of adult offspring. Neurosteroid synthesis was assessed in terms of changes in the activity of 5α-reductase, the enzyme which converts progesterone into active metabolites. Prenatal stress results in a significant decrease in the level of anxiety and an increase in movement activity among adult males. Stressed rats showed increases in progesterone-5α-reductase activity in the hypothalamus, hippocampus, and frontal cortex. These results provide evidence that changes in the behavior of adult male rats due to stress in the prenatal period of development may be due to the formation of active progesterone metabolites in the brain.

prenatal stressneurosteroids5alpha-reductasebehavior

Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  • N. É. Ordyan
    • 1
  • S. G. Pivina
    • 1
  1. 1.I. P. Pavlov Institute of Physiology, Russian Academy of SciencesSt. PetersburgRussia