, Volume 8, Issue 2, pp 215-223

NF-κB in Mammary Gland Development and Breast Cancer

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Abstract

Nuclear factor of κB (NF-κB) is a group of sequence-specific transcription factors that is best known as a key regulator of the inflammatory and innate immune responses. Recent studies of genetically engineered mice have clearly indicated that NF-κB is also required for proper organogenesis of several epithelial tissues, including the mammary gland. Mice have shown severe lactation deficiency when NF-κB activation is specifically blocked in the mammary gland. In addition, there are strong suggestions that NF-κB may play an important role in the etiology of breast cancer. Elevated NF-κB DNA-binding activity is detected in both mammary carcinoma cell lines and primary human breast cancer tissues.