Cancer and Metastasis Reviews

, Volume 23, Issue 1, pp 53–61

TGFβ and Wnt pathway cross-talk

Authors

  • Liliana Attisano
    • Department of Biochemistry and Department of Medical BiophysicsUniversity of Toronto
  • Etienne Labbé
    • Department of Medical BiophysicsUniversity of Toronto
Article

DOI: 10.1023/A:1025811012690

Cite this article as:
Attisano, L. & Labbé, E. Cancer Metastasis Rev (2004) 23: 53. doi:10.1023/A:1025811012690

Abstract

Transforming growth factor-βs (TGFβ) and Wnts represent two distinct families of secreted molecules each of which utilizes different signaling pathways to elicit their biological effects. These factors regulate numerous developmental events and mutations in components of both pathways have been described in human cancers including colorectal carcinomas. Several studies have demonstrated that TGFβ and Wnt ligands can cooperate to regulate differentiation and cell fate determination by controlling gene expression patterns. In addition, their cooperation in promoting tumorigenesis in mice has been described. Here, we focus on reviewing our current understanding of the molecular mechanisms that may mediate these cooperative effects.

TGFβWntsignal transductionsmadscancer

Copyright information

© Kluwer Academic Publishers 2004