Bulletin of Experimental Biology and Medicine

, Volume 135, Issue 6, pp 590–592

Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells

Authors

    • North-Western Division of Russian Academy of Medical SciencesSt. Petersburg Institute of Bioregulation and Gerontology
  • I. E. Bondarev
    • North-Western Division of Russian Academy of Medical SciencesSt. Petersburg Institute of Bioregulation and Gerontology
  • A. A. Butyugov
    • North-Western Division of Russian Academy of Medical SciencesSt. Petersburg Institute of Bioregulation and Gerontology
Article

DOI: 10.1023/A:1025493705728

Cite this article as:
Khavinson, V.K., Bondarev, I.E. & Butyugov, A.A. Bulletin of Experimental Biology and Medicine (2003) 135: 590. doi:10.1023/A:1025493705728

Abstract

Addition of Epithalon peptide in telomerase-negative human fetal fibroblast culture induced expression of the catalytical subunit, enzymatic activity of telomerase, and telomere elongation, which can be due to reactivation of telomerase gene in somatic cells and indicates the possibility of prolonging life span of a cell population and of the whole organism.

peptideEpithalontelomerasetelomeresfibroblasts

Copyright information

© Plenum Publishing Corporation 2003