Article

Bulletin of Experimental Biology and Medicine

, Volume 135, Issue 6, pp 590-592

Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells

  • V. Kh. KhavinsonAffiliated withNorth-Western Division of Russian Academy of Medical Sciences, St. Petersburg Institute of Bioregulation and Gerontology Email author 
  • , I. E. BondarevAffiliated withNorth-Western Division of Russian Academy of Medical Sciences, St. Petersburg Institute of Bioregulation and Gerontology
  • , A. A. ButyugovAffiliated withNorth-Western Division of Russian Academy of Medical Sciences, St. Petersburg Institute of Bioregulation and Gerontology

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Abstract

Addition of Epithalon peptide in telomerase-negative human fetal fibroblast culture induced expression of the catalytical subunit, enzymatic activity of telomerase, and telomere elongation, which can be due to reactivation of telomerase gene in somatic cells and indicates the possibility of prolonging life span of a cell population and of the whole organism.

peptide Epithalon telomerase telomeres fibroblasts