Prenatal factors and use of anti-asthma medications in early childhood: A population-based Danish birth cohort study Article DOI:
10.1023/A:1025390420122 Cite this article as: Yuan, W., Fonager, K., Olsen, J. et al. Eur J Epidemiol (2003) 18: 763. doi:10.1023/A:1025390420122 Abstract
To examine whether fetal growth indicators and other prenatal factors were associated with the use of anti-asthma medications during the first year of life, we conducted a follow-up study based on birth registry and prescription registry data of the county of North Jutland, Denmark. We identified 9705 singletons born between 1 April 1996 and 31 December 1997. They were followed to the end of the first year of life by linkage with a prescription registry. Prescription for asthma was defined as both a β-agonist and an inhaled glucocorticoid prescription. A prescription for asthma was presented to 3.8% of the infants during the first year of life. Maternal asthma, male gender, maternal smoking, multiparous births, young maternal age, and maternal non-cohabitation were associated with the risk of receiving a prescription for asthma. There were slightly increased trends in the risk with birth weight and placental weight. The increased risk was more pronounced in the groups of birth weight ≥3800 g (adjusted OR: 1.23, 95% CI: 0.88–1.73) and placental weight ≥750 g (adjusted OR: 1.44, 95% CI: 1.10–1.88). The increased risk was also associated with a high ponderal index of ≥2.7 g/cm
3 (adjusted OR: 1.37, 95% CI: 1.06–1.76). Asthma Fetal growth Infant Prenatal Risk factors References
Lodrup Carlsen KC, Carlsen KH, Nafstad P, Bakketeig L. Perinatal risk factors for recurrent wheeze in early life. Pediatr Allergy Immunol 1999; 10: 89–95.
Oliveti JF, Kercsmar CM, Redline S. Pre-and perinatal risk factors for asthma in inner city African-American children. Am J Epidemiol 1996; 143: 570–577.
Seidman DS, Laor A, Gale R, Stevenson DK, Danon YL. Is low birth weight a risk factor for asthma during adolescence? Arch Dis Child 1991; 66: 584–587.
Steffensen FH, Sorensen HT, Gillman MW, et al. Low birth weight and preterm delivery as risk factors for asthma and atopicdermatitis in young adult males. Epidemiology 2000; 11: 185–188.
Hagstrom B, Nyberg P, Nilsson PM. Asthma in adult life - is there an association with birth weight? Scand J Prim Health Care 1998; 16: 117–120.
Gregory A, Doull I, Pearce N, et al. The relationship between anthropometricmeasurements at birth: Asthma and atopy in childhood. Clin Exp Allergy 1999; 29: 330–333.
Leadbitter P, Pearce N, Cheng S, et al. Relationship between fetal growth and the development of asthma and atopy in childhood. Thorax 1999; 54: 905–910.
Rasanen M, Kaprio J, Laitinen T, Winter T, Koskenvuo M, Laitinen LA. Perinatal risk factors for asthma in Finnish adolescent twins. Thorax 2000; 55: 25–31.
Gaist D, Sorensen HT, Hallas J. The Danish prescription registries. Dan Med Bull 1997; 44: 445–448.
Vollmer WM, Hertert S, Allison MJ. Recruiting children and their families for clinical trials: A case study. Control Clin Trials 1992; 13: 315–320.
Osborne ML, Vollmer WM, Johnson RE, Buist AS. Use of an automated prescription database to identify individuals with asthma. J Clin Epidemiol 1995; 48: 1393–1397.
Hosmer DW, Lemeshow S. Assessing the fit of the model. In: Hosmer DW, Lemeshow S (eds), Applied Logistic Regression, New York: John Wiley & Sons, 2000; 143–202.
Sears MR, Holdaway MD, Flannery EM, Herbison GP, Silva PA. Parental and neonatal risk factors for atopy, airway hyper-responsiveness, and asthma. Arch Dis Child 1996; 75: 392–398.
Halonen M, Stern D, Taussig LM, Wright A, Ray CG, Martinez FD. The predictive relationship between serum IgE levels at birth and subsequent incidences of lower respiratory illnesses and eczema in infants. Am Rev Respir Dis 1992; 146: 866–870.
Tepper RS, Morgan WJ, Cota K, Wright A, Taussig LM. Physiologicgrowth and development of the lung during the first year of life. Am Rev Respir Dis 1986; 134: 513–519.
Pagtakhan RD, Bjelland JC, Landau LI, et al. Sex differences in growth patterns of the airways and lung parenchyma in children. J Appl Physiol 1984; 56: 1204–1210.
Agabiti N, Mallone S, Forastiere F, et al. The impact of parental smoking on asthma and wheezing. SIDRIA Collaborative Group. Epidemiology 1999; 10: 692–698.
Lodrup Carlsen KC, Jaakkola JJ, Nafstad P, Carlsen KH. In utero exposure to cigarette smoking influences lung function at birth. Eur Respir J 1997; 10: 1774–1779.
Magnusson CG. Maternal smoking influences cord serum IgE and IgD levels and increases the risk for subsequent infant allergy. J Allergy Clin Immunol 1986; 78: 898–904.
Atici A, Altintas D, Yuksel B, et al. Do parental smoking and history of allergy influence cord-serum IgE? Pediatr Allergy Immunol 1995; 6: 213–215.
Strachan DP, Moran SE, McInneny K, Smalls M. Reduced risk of hospital admission for childhood asthma among Scottish twins: Record linkage study. Br med J 2000; 321: 732–733.
Fergusson DM, Crane J, Beasley R, Horwood LJ. Perinatal factors and atopic disease in childhood. Clin Exp Allergy 1997; 27: 1394–1401.
Martinez FD. Maternal risk factors in asthma. Ciba Found Symp 1997; 206: 233–239.
Braback L, Hedberg A. Perinatal risk factors for atopic disease in conscripts. Clin Exp Allergy 1998; 28: 936–942.
Rona RJ, Hughes JM, Chinn S. Association between asthma and family size between 1977 and 1994. J Epidemiol Commun Health 1999; 53: 15–19.
Wickens KL, Crane J, Kemp TJ, et al. Family size, infections, and asthma prevalence in New Zealand children. Epidemiology 1999; 10: 699–705.
Karmaus W, Botezan C. Does a higher number of siblings protect against the development of allergy and asthma? A review. J Epidemiol Commun Health 2002; 56: 209–217.
Cookson WO, Moffatt MF. Asthma: An epidemicin the absence of infection? Science 1997; 275: 41–42.
Matricardi PM, Ronchetti R. Are infections protecting from atopy? Curr Opin Allergy Clin Immunol 2001; 1: 413–419.
Chandra RK, Puri S, Suraiya C, Cheema PS. Influence of maternal food antigen avoidance during pregnancy and lactation on incidence of atopic eczema in infants. Clin Allergy 1986; 16: 563–569.
Wjst M, Dold S. Is asthma an endocrine disease? Pediatr Allergy Immunol 1997; 8: 200–204.
Godfrey KM, Barker DJ. Maternal nutrition in relation to fetal and placental growth. Eur J Obstet Gynecol Reprod Biol 1995; 61: 15–22.
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