Novel Polyester-Polysaccharide Nanoparticles
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
Purpose. The aim of the present study was to develop a new type of core-shell nanoparticles from a family of novel amphiphilic copolymers, based on dextran (DEX) grafted with poly(ε–caprolactone) (PCL) side chains (PCL-DEX).
Methods. A family of PCL-DEX copolymers was synthesized in which both the molecular weight and the proportion by weight of DEX in the copolymer were varied. The nanoparticles were prepared by a technique derived from emulsion-solvent evaporation, during which emulsion stability was investigated using a Turbiscan. The nanoparticle size distribution, density, zeta potential, morphology, and suitability for freeze-drying were determined.
Results. Because of their strongly amphiphilic properties, the PCL-DEX copolymers were able to stabilize o/w emulsions without the need of additional surfactants. Nanoparticles with a controlled mean diameter ranging from 100 to 250 nm were successfully prepared. A mechanism of formation of these nanoparticles was proposed. Zeta potential measurements confirmed the presence of a DEX coating.
Conclusion. A new generation of polysaccharide-decorated nanoparticles has been successfully prepared from a family of PCL-DEX amphiphilic copolymers. They may have potential applications in drug encapsulation and targeting.
- R. Gref, Y. Minamitake, M. T. Peracchia, V. Trubetskoy, V. Torchilin, and R. Langer. Biodegradable long-circulating polymeric nanospheres. Science 263:1600-1603 (1994).
- D. Bazile, C. Prud'homme, M. T. Bassoullet, M. Marlard, G. Spenlehauer, and M. Veillard. Stealth MePEG-PLA nanoparticles avoid uptake by the mononuclear phagocytes system. J. Pharm. Sci. 84:493-498 (1995).
- M. T. Peracchia, C. Vauthier, D. Desmaele, A. Gulik, J. C. Dedieu, M. Demoy, J. d'Angelo, and P. Couvreur. Pegylated nanoparticles from a novel methoxypolyethylene glycol cyanoacrylate-hexadecyl cyanoacrylate amphiphilic copolymer. Pharm. Res. 15:550-556 (1998).
- B. Stella, S. Arpicco, M. T. Peracchia, D. Desmaele, J. Hoebeke, M. Renoir, J. D'Angelo, L. Cattel, and P. Couvreur. Design of folic acid-conjugated nanoparticles for drug targeting. J. Pharm. Sci. 89:1452-1464 (2000).
- E. Österberg, K. Bergstrom, K. Holmberg, T. P. Schuman, J. A. Riggs, N. L. Burns, J. M. Van Alstine, and J. M. Harris. Protein-rejecting ability of surface-bound dextran in end-on and side-on configurations: comparison to PEG. J. Biomed. Mater. Res. 29:741-747 (1995).
- C. Rouzes, R. Gref, M. Leonard, A. De Sousa Delgado, and E. Dellacherie. Surface modification of poly(lactic acid) nanospheres using hydrophobically modified dextrans as stabilizers in an o/w emulsion/evaporation technique. J. Biomed. Mater. Res. 50:557-565 (2000).
- Y. Ohya, S. Maruhashi, and T. Ouchi. Preparation of poly(lactic acid)-grafted amylose through the trimethylsilyl protection method and its biodegradation. Macromol. Chem. Phys. 199:2017-2022 (1998).
- Y. Li, C. Volland, and T. Kissel. Biodegradable brush-like graft polymers from poly(D,L-lactide) or poly(D,L-lactide-coglycolide) and charge-modified, hydrophilic dextrans as backbone-in vitro degradation and controlled releases of hydrophilic macromolecules. Polymer 39:3087-3097 (1998).
- G. Schwach, J. Coudane, R. Engel, and M. Vert. More about the polymerization of lactides in the presence of stannous octoate. J. Polym. Sci. Pol. Chem. 35:3431-3440 (1997).
- R. Gref, J. Rodrigues, and P. Couvreur. Polysaccharides grafted with polyesters: novel amphiphilic copolymers for biomedical applications. Macromolecules 35:9861-9867 (2002).
- J. Brandrup, E.H. Immergut, E.A. Grulke, A. Abe, and D.R. Bloch. Polymer Handbook. J. Wiley and sons, New York, 1999.
- C. G. Pitt. Poly-ɛ-caprolactone and its copolymers. In M. Chasin and R. Langer (eds.), Biodegradable polymers as drug delivery systems. Marcel Dekker, New York, 1990, pp. 71-120.
- P. D. Scholes, A. G. Coombes, L. Illum, S. S. Davis, J. F. Watts, C. Ustariz, M. Vert, and M. C. Davies. Detection and determination of surface levels of poloxamer and PVA surfactant on biodegradable nanospheres using SSIMS and XPS. J. Control. Release 59:261-278 (1999).
- J. Briant. PhÉnomÈnes d'interface: Agents de Surface. Editions Technip, Paris, 1989.
- P. Quellec, R. Gref, L. Perrin, E. Dellacherie, F. Sommer, J. M. Verbavatz, and M. J. Alonso. Protein encapsulation within polyethylene glycol-coated nanospheres. I. Physicochemical characterization. J. Biomed. Mater. Res. 42:45-54 (1998).
- O. Mengual, G. Meunier, I. Cayre, K. Puech, and P. Snabre. Characterisation of instability of concentrated dispersions by a new optical analyser: the TURBISCAN MA 1000. Colloids Surf. A. Physicochem. Eng. Aspects 152:111-123 (1999).
- R. Bodmeier and J. W. McGinity. Solvent selection in the preparation of poly(DL-lactide) microspheres prepared by the solvent evaporation method. Int. J. Pharm. 43:179-186 (1988).
- D. H. Napper. Steric stabilization. J. Colloid Interface Sci. 58:390-407 (1977).
- Novel Polyester-Polysaccharide Nanoparticles
Volume 20, Issue 8 , pp 1284-1292
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers-Plenum Publishers
- Additional Links
- amphiphilic copolymer
- Industry Sectors