Article

Chromosome Research

, Volume 11, Issue 5, pp 527-536

First online:

Nuclear microenvironments support physiological control of gene expression

  • Gary S. SteinAffiliated withDepartment of Cell Biology and Cancer Center, University of Massachusetts Medical School
  • , Jane B. LianAffiliated withDepartment of Cell Biology and Cancer Center, University of Massachusetts Medical School
  • , Martin MontecinoAffiliated withDepartamento de Biologia Molecular, Facultad de Ciencias Biologicas, Universidad de Concepcion
  • , Janet L. SteinAffiliated withDepartment of Cell Biology and Cancer Center, University of Massachusetts Medical School
  • , André J. van WijnenAffiliated withDepartment of Cell Biology and Cancer Center, University of Massachusetts Medical School
  • , Amjad JavedAffiliated withDepartment of Cell Biology and Cancer Center, University of Massachusetts Medical School
  • , Jitesh PratapAffiliated withDepartment of Cell Biology and Cancer Center, University of Massachusetts Medical School
  • , Je ChoiAffiliated withKyungpook National University
  • , S. Kaleem ZaidiAffiliated withDepartment of Cell Biology and Cancer Center, University of Massachusetts Medical School
    • , Soraya GutierrezAffiliated withDepartamento de Biologia Molecular, Facultad de Ciencias Biologicas, Universidad de Concepcion
    • , Kimberly HarringtonAffiliated withDepartment of Cell Biology and Cancer Center, University of Massachusetts Medical School
    • , Jiali ShenAffiliated withDepartment of Cell Biology and Cancer Center, University of Massachusetts Medical School
    • , Daniel YoungAffiliated withDepartment of Cell Biology and Cancer Center, University of Massachusetts Medical School
    • , Shirwin PockwinseAffiliated withDepartment of Cell Biology and Cancer Center, University of Massachusetts Medical School

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Abstract

There is growing recognition that the organization of nucleic acids and regulatory proteins is functionally linked to the assembly, localization and activity of gene regulatory machinery. Cellular, molecular, biochemical and in-vivo genetic evidence support an obligatory relationship between nuclear microenvironments where regulatory complexes reside and fidelity of transcriptional control. Perturbations in mechanisms governing the intranuclear trafficking of transcription factors and the temporal/spatial organization of regulatory proteins within the nucleus occur with compromised gene expression that abrogates skeletal development and mediates leukemogenesis.

cell nucleus chromatin gene expression nucleosome osteocalcin RUNX proteins