Therapy related hospital admission in patients on polypharmacy in Singapore: a pilot study
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Objective: To estimate the incidence of drug-related problems (DRPs)‐associated hospital admission, and its correlation to polypharmacy and age.Method: A retrospective, cross‐sectional study in in-patients on polypharmacy in Singapore. Significant differences (p < 0.05) between number of medications taken and age of patients were tested with the chi‐square test.Results: The study population consisted of 347 patients (aged 16–97) on a mean of 7.4 ± 2.1 medications. 10.8% of the study population had DRPs on admission: 71.9% of which were dominant reasons for admission, and DRPs contributed partly in the remaining cases. These DRPs were mostly avoidable, and can be broadly classified into non‐compliance, adverse drug reactions, require synergistic therapy, inappropriate dose and untreated condition. 52% of these cases were made up of geriatric patients. No statistical difference was found between patients on polypharmacy and those on major polypharmacy (10 and more drugs) in having a DRP.Conclusion: In this study, DRPs contributing to hospital admission appeared to be avoidable. Geriatrics were more susceptible to DRPs and future efforts are required in managing medications prescribed for these patients to reduce such incidences.
- Bergman U, Wiholm BE. Drug-related problems causing admission to a medical clinic. Eur J Clin Pharmacol 1981; 20(3): 193–200.
- Beijer HJM, De Blaey CJ. Hospitalisations caused by adverse drug reactions (ADR): a meta-analysis of obervational studies. Pharm World Sci 2002; 24(2): 46–54.
- Montamat SC, Cusack B. Overcoming problems with polypharmacy and drug misuse in the elderly. Clin Geriatr Med 1992; 8(1): 143–58.
- Nolan L, O'Malley K. Prescribing for the elderly: part 1. Sensitivity of the elderly to adverse drug reactions. J Am Geriatr Soc 1988; 36(2): 142–9.
- Stewart RB, Cooper JW. Polypharmacy in the aged. Practical solutions. Drugs Aging 1994; 4(6): 449–61.
- Van den Bemt PMLA, Egberts ACG, Lenderink AW, Verzijl JM, Simons KA, Van der Pol WSCJM, Leufkens HGM. Risk factors for the development of adverse drug events in hospitalized patients. Pharm World Sci 2000; 22(2): 62–6.
- Hulka BS, Kupper LL, Cassee JC, Efird, RL. Medication use and misuse: physician-patient discrepancies. J Chronic Disease 1975; 28(1): 7–21.
- Hurwitz N. Predisposing factors in adverse reactions to drugs. BMJ 1969; 1(643): 536–9.
- Brawn LA, Castleden CM. Adverse drug reactions. An overview of special considerations in the management of the elderly patient. Drug Saf 1990; 5(6): 421–35.
- Hoigné R, Lawson DH, Weber E. Risk factors for adverse drug reactions - epidemiological approaches. Eur J Clin Pharmacol 1990; 39(4): 321–5.
- Lindley CM, Tully MP, Paramsothy V, Tallis RC. Inappropriate medication is a major cause of adverse drug reactions in elderly patients. Age Ageing 1992; 21(4): 294–300.
- Classen DC, Pestotnik SL, Evans RS, Lloyd JF, Burke JP. Adverse drug events in hospitalized patients. Excess length of stay, extra costs, and attributable mortality. JAMA 1997; 277(4): 301–6.
- Hallas J, Harvald B, Gram LF, Grodum E, Brøsen K, Haghfelt T et al. Drug related hospital admissions: the role of definitions and intensity of data collection, and the possibility of prevention. J Intern Med 1990; 228(2): 83–90.
- Courtman BJ, Stallings SB. Characterisation of drug-related problems in elderly patients on admission to a medical ward. Can J Hosp Pharm 1995; 48(3): 161–6.
- Therapy related hospital admission in patients on polypharmacy in Singapore: a pilot study
Pharmacy World and Science
Volume 25, Issue 4 , pp 135-137
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