Journal of Biological Physics

, Volume 29, Issue 2, pp 117–121

Terahertz Time-Domain Spectroscopy of Glucose and Uric Acid


  • P.C. Upadhya
    • Cavendish LaboratoryUniversity of Cambridge
  • Y.C. Shen
    • Cavendish LaboratoryUniversity of Cambridge
  • A.G. Davies
    • School of Electronic and Electrical EngineeringUniversity of Leeds
  • E.H. Linfield
    • Cavendish LaboratoryUniversity of Cambridge

DOI: 10.1023/A:1024476322147

Cite this article as:
Upadhya, P., Shen, Y., Davies, A. et al. Journal of Biological Physics (2003) 29: 117. doi:10.1023/A:1024476322147


We report the use ofterahertz time-domain spectroscopy for thestudy of two therapeutic bio-molecules:glucose and uric acid. Terahertztransmission spectra of crystalline samplesof both molecules were measured between 0.1–3.0 THz using an evacuated spectroscopysystem. We propose that the stereo-isomersof glucose show spectral featuresoriginating from intermolecular vibrationalmodes, as do uric acid and its derivativemolecule, allantoin. In addition, wepresent a full temperature dependence ofthe terahertz absorption of L-glucose.

Glucoseintermoleculartemperature dependent absorptionterahertztime-domain spectroscopyuric acid

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© Kluwer Academic Publishers 2003