Journal of Autism and Developmental Disorders

, Volume 33, Issue 3, pp 343–348

The HOXA1 A218G Polymorphism and Autism: Lack of Association in White and Black Patients from the South Carolina Autism Project

Authors

  • Julianne S. Collins
    • Greenwood Genetic CenterJ. C. Self Research Institute
  • Richard J. Schroer
    • Greenwood Genetic CenterJ. C. Self Research Institute
  • Jeffrey Bird
    • Greenwood Genetic CenterJ. C. Self Research Institute
    • Greenwood Genetic CenterJ. C. Self Research Institute
Article

DOI: 10.1023/A:1024414803151

Cite this article as:
Collins, J.S., Schroer, R.J., Bird, J. et al. J Autism Dev Disord (2003) 33: 343. doi:10.1023/A:1024414803151

Abstract

A recent study has suggested that the A218G polymorphism in the homeobox Al (HOXA1) gene may influence susceptibility to autism. We have determined the frequencies of the A and G alleles of the HOXA1 A218G polymorphism in both white and black patients from the South Carolina Autism Project (SCAP) and controls. Marked differences were found in allele frequencies between the races, but no deviations from Hardy-Weinberg equilibrium were seen in either white or black SCAP family members. More direct tests, comparing genotype frequencies between probands and controls and tracking transmission of the A versus G alleles to affected offspring, did not support the contention that allele status for the HOXA1 A218G polymorphism influences one's susceptibility to autism.

Neurobehavioral disorderssingle nucleotide polymorphismhomeobox genes

Copyright information

© Plenum Publishing Corporation 2003