Journal of Biological Physics

, Volume 29, Issue 2, pp 257–259

Terahertz Pulsed Imaging of Skin Cancer in the Time and Frequency Domain

Authors

  • R.M. Woodward
    • TeraView Limited, 302/304 Science Park
    • Cavendish LaboratoryUniversity of Cambridge
  • V.P. Wallace
    • TeraView Limited, 302/304 Science Park
  • D.D. Arnone
    • TeraView Limited, 302/304 Science Park
  • E.H. Linfield
    • Cavendish LaboratoryUniversity of Cambridge
  • M. Pepper
    • Cavendish LaboratoryUniversity of Cambridge
Article

DOI: 10.1023/A:1024409329416

Cite this article as:
Woodward, R., Wallace, V., Arnone, D. et al. Journal of Biological Physics (2003) 29: 257. doi:10.1023/A:1024409329416

Abstract

Terahertz Pulsed Imaging(TPI) is a new medical imaging modality forthe detection of epithelial cancers. Overthe last two years this technique has beenapplied to the study of in vitrobasal cell carcinoma (BCC). Usingtime-domain analysis the contrast betweendiseased and normal tissue has been shownto be statistically significant, andregions of increased terahertz (THz)absorption correlated well with thelocation of the tumour sites in histology.Understanding the source of this contrastthrough frequency-domain analysis mayfacilitate the diagnosis of skin cancer andrelated skin conditions using TPI. Wepresent the first frequency-domain analysisof basal cell carcinoma in vitro,with the raw power spectrum giving aninsight into the surface features of theskin. Further data manipulation is requiredto determine whether spectral informationcan be extrapolated at depth. These resultshighlight the complexity of working inreflection geometry.

Cancerepithelialfrequency domainskinterahertz imagingtime domain spectroscopy

Copyright information

© Kluwer Academic Publishers 2003