Breast Cancer Research and Treatment

, Volume 80, Issue 1, pp 79–85

Expression of Estrogen Receptor-β in Normal Mammary and Tumor Tissues: is it Protective in Breast Carcinogenesis?

Authors

  • Byeong-Woo Park
    • Department of SurgeryYonsei University College of Medicine
    • Brain Korea 21 ProjectYonsei University College of Medicine
  • Ki-Suk Kim
  • Min-Kyu Heo
  • Seung-Sang Ko
    • Department of SurgeryYonsei University College of Medicine
  • Kyong Sik Lee
    • Department of SurgeryYonsei University College of Medicine
  • Soon Won Hong
    • Department of Internal MedicineYonsei University College of Medicine
  • Woo-Ick Yang
    • Department of Internal MedicineYonsei University College of Medicine
  • Joo-Hang Kim
    • Brain Korea 21 ProjectYonsei University College of Medicine
  • Gwi Eon Kim
    • Brain Korea 21 ProjectYonsei University College of Medicine
Article

DOI: 10.1023/A:1024406223619

Cite this article as:
Park, B., Kim, K., Heo, M. et al. Breast Cancer Res Treat (2003) 80: 79. doi:10.1023/A:1024406223619

Abstract

Using messenger RNA (mRNA) in situ hybridization, we investigated estrogen receptor-β (ERβ) mRNA levels in normal mammary, benign breast tumor (BBT), breast cancer (BC), and metastatic lymph node tissues to verify the role of ERβ in BC development and progression. ERβ expression was significantly decreased in BC and metastatic lymph node tissues compared with normal mammary and BBT tissues (p < 0.01). The intensity and extent of ERβ mRNA signals were also significantly lower in BC and metastatic lymph node tissues than in the normal mammary and BBT tissues (p < 0.01). An inverse relationship was found between ERβ mRNA level and both histologic grade (p = 0.091) and progesterone receptor expression (p = 0.052) with marginal significance, but no significant association was noted between ERβ expression in cancer tissues and the other clinico-pathologic data. The 3-year distant relapse-free survival probability was found to be independent of ERβ expression. Collectively, ERβ mRNA decreases in the process of BC development, but seems to be associated with poor differentiation.

breast cancercarcinogenesisestrogen receptor-βin situ hybridizationprognosis

Copyright information

© Kluwer Academic Publishers 2003