, Volume 4, Issue 3, pp 167–170

Immunosenescence and human longevity

  • Graham Pawelec

DOI: 10.1023/A:1024185405946

Cite this article as:
Pawelec, G. Biogerontology (2003) 4: 167. doi:10.1023/A:1024185405946


Humans are almost certainly the longest-living of all mammals. What explains their longevity? Are there evolutionary pressures favouring longer life and if so what are they? If longevity is a positively selected trait, are many or few genes responsible for this characteristic? It is proposed here that human longevity was selected for at the level of relatively few genes and that many of these are involved in regulating the immune system.

cytokineimmune risk phenotypeimmunosenescenceinflammationlongevityT cell response

Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Graham Pawelec
    • 1
  1. 1.Center for Medical ResearchUniversity of TübingenTübingenGermany