Journal of Materials Science: Materials in Medicine

, Volume 14, Issue 7, pp 641–645

Synthesis and biocompatibility of porous nano-hydroxyapatite/collagen/alginate composite

Authors

  • S. M. Zhang
    • Department of Materials Science &Engineering, Tsinghua University
    • Department of Materials Science &Engineering, Tsinghua University
  • S. S. Liao
    • Department of Materials Science &Engineering, Tsinghua University
  • Y. Zhu
    • Department of Materials Science &Engineering, Tsinghua University
  • L. Han
    • Department of Materials Science &Engineering, Tsinghua University
Article

DOI: 10.1023/A:1024083309982

Cite this article as:
Zhang, S.M., Cui, F.Z., Liao, S.S. et al. Journal of Materials Science: Materials in Medicine (2003) 14: 641. doi:10.1023/A:1024083309982

Abstract

Porous nano-hydroxyapatite/collagen/alginate (nHAC/Alginate) composite containing nHAC and Ca-crosslinked alginate is synthesized biomimetically. This composite shows a significant improvement in mechanical properties over nHAC material. Mechanical test results show that the compressive modulus and yield strength of this composite are in direct proportion to the percentage of Ca-crosslinked alginate in the composite. Primary biocompatibility experiments in vitro including fibroblasts and osteoblasts co-culture with nHAC/alginate composite indicated the high biocompatibility of this composite. Therefore the composite can be a promising candidate of scaffold material for bone tissue engineering.

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© Kluwer Academic Publishers 2003