Article

Journal of Materials Science: Materials in Medicine

, Volume 14, Issue 7, pp 641-645

First online:

Synthesis and biocompatibility of porous nano-hydroxyapatite/collagen/alginate composite

  • S. M. ZhangAffiliated withDepartment of Materials Science &, Engineering, Tsinghua University
  • , F. Z. CuiAffiliated withDepartment of Materials Science &, Engineering, Tsinghua University Email author 
  • , S. S. LiaoAffiliated withDepartment of Materials Science &, Engineering, Tsinghua University
  • , Y. ZhuAffiliated withDepartment of Materials Science &, Engineering, Tsinghua University
  • , L. HanAffiliated withDepartment of Materials Science &, Engineering, Tsinghua University

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Abstract

Porous nano-hydroxyapatite/collagen/alginate (nHAC/Alginate) composite containing nHAC and Ca-crosslinked alginate is synthesized biomimetically. This composite shows a significant improvement in mechanical properties over nHAC material. Mechanical test results show that the compressive modulus and yield strength of this composite are in direct proportion to the percentage of Ca-crosslinked alginate in the composite. Primary biocompatibility experiments in vitro including fibroblasts and osteoblasts co-culture with nHAC/alginate composite indicated the high biocompatibility of this composite. Therefore the composite can be a promising candidate of scaffold material for bone tissue engineering.