Effect of Oxotremorine on Resting Membrane Potential and Cell Volume in Skeletal Muscle Fibers in Rats after in Vivo Blockade of NO-Synthase
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Denervation of rat phrenic muscle or block of NO-synthase in vivo increased the cross-section area of muscle fibers and decreased membrane resting potential. Oxotremorine prevented the development of denervation-induced or denervation-like (i.e. induced by NO-synthase blockade) membrane depolarization and increase of the cross-sectional area of muscle fibers. Pirenzepine abolished the effects of oxotremorine. It was concluded that non-quantal acetylcholine can be involved in the regulation of skeletal muscle fiber volume via activation of M1 muscarinic receptors followed by NO synthesis.
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- Effect of Oxotremorine on Resting Membrane Potential and Cell Volume in Skeletal Muscle Fibers in Rats after in Vivo Blockade of NO-Synthase
Bulletin of Experimental Biology and Medicine
Volume 135, Issue 2 , pp 120-122
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- skeletal muscle
- neuromuscular synapse
- cell volume
- M1 muscarinic receptors
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