Effect of Oxotremorine on Resting Membrane Potential and Cell Volume in Skeletal Muscle Fibers in Rats after in Vivo Blockade of NO-Synthase
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- Khairova, R.A., Malomuzh, A.I., Naumenko, N.V. et al. Bulletin of Experimental Biology and Medicine (2003) 135: 120. doi:10.1023/A:1023899210383
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Denervation of rat phrenic muscle or block of NO-synthase in vivo increased the cross-section area of muscle fibers and decreased membrane resting potential. Oxotremorine prevented the development of denervation-induced or denervation-like (i.e. induced by NO-synthase blockade) membrane depolarization and increase of the cross-sectional area of muscle fibers. Pirenzepine abolished the effects of oxotremorine. It was concluded that non-quantal acetylcholine can be involved in the regulation of skeletal muscle fiber volume via activation of M1 muscarinic receptors followed by NO synthesis.