Neuropsychology Review

, Volume 13, Issue 2, pp 79–92

Alzheimer' Disease as a Disconnection Syndrome?


DOI: 10.1023/A:1023832305702

Cite this article as:
Delbeuck, X., Van der Linden, M. & Collette, F. Neuropsychol Rev (2003) 13: 79. doi:10.1023/A:1023832305702


This paper reviews the growing amount of evidence supporting the hypothesis that Alzheimer's disease includes a disconnection syndrome. This evidence came mainly from neuropathological, electrophysiological, and neuroimaging studies. Moreover, a few recent neuropsychological studies have also explored the effects of a disconnection between cerebral areas on cognitive functioning. Finally, and more generally, the contribution of this interpretation to the understanding of Alzheimer's disease cognitive deficits is considered.

Alzheimer's diseasedisconnectionneuropsychology

Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  1. 1.Cognitive Psychopathology UnitUniversity of GenevaGenevaSwitzerland
  2. 2.Neuropsychology DepartmentUniversity of LiégeLiégeBelgium