Article

Cancer and Metastasis Reviews

, Volume 22, Issue 4, pp 395-403

First online:

Role of MAP kinase in tumor progression and invasion

  • Kaladhar B. ReddyAffiliated withDepartment of Pathology, Wayne State University School of Medicine Email author 
  • , Sanaa M. NabhaAffiliated withDepartment of Pathology, Wayne State University School of Medicine
  • , Natasha AtanaskovaAffiliated withDepartment of Pathology, Wayne State University School of Medicine

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Abstract

Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway is a frequent event in tumorigenesis. MAPKs have been implicated in cell migration, proteinase-induction, regulation of apoptosis, and angiogenesis, events that are essential for successful completion of metastasis. In this review, we discuss the potential role that MAPKs play in metastasis by regulating cell migration, proteinase-induction and apoptosis.

apoptosis invasion MAPK metastasis migration proteinases