Cancer and Metastasis Reviews

, Volume 22, Issue 4, pp 301–307

Epidermal growth factor receptor family tyrosine kinases as signal integrators and therapeutic targets


DOI: 10.1023/A:1023726827771

Cite this article as:
Barnes, C.J. & Kumar, R. Cancer Metastasis Rev (2003) 22: 301. doi:10.1023/A:1023726827771


Activating mutations, gene amplification and overexpression of human epidermal growth factor receptor (erbB or HER) family kinases have been implicated as integral contributors to a variety of cancers. However, there is increasing evidence that the HER family receptors propagate not only signals initiated by their own ligands but also those initiated by multiple other signaling pathways. Attenuation of HER family signaling is a developing strategy for the management of human malignancies and is the subject of a number of ongoing clinical trials. The purpose of this review is to provide a timely update of recent reports in the rapidly evolving area of HER family biology and the emerging integral role of these receptors in malignant transformation and as targets of cancer therapy.


Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  1. 1.Department of Molecular and Cellular OncologyThe University of Texas M. D. Anderson Cancer CenterHoustonUSA