Thiamine Deficiency-Induced Disruptions in the Diurnal Rhythm and Regulation of Body Temperature in the Rat
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
In the present study, diurnal rhythm and regulation of body temperature were monitored during and several weeks following pyrithiamine-induced thiamine deficiency (PTD group, n=8) or pairfeeding (control group, n=9). A significant decline of core body temperature and a disruption of its diurnal rhythm were observed at varying stages of PTD treatment. Following thiamine administration and return to thiamine-fortified chow, body temperature continued to fall and several days transpired before body temperature and its diurnal rhythm were returned to normal. When exposed to warm and cold environments, no significant group differences were observed in either the maximum temperature change or the time elapsed to reach maximal temperature change. Histological examination revealed necrotic lesions in thalamus and mammillary body in the PTD group characteristic of Wernicke's encephalopathy. No significant damage was observed in the medial preoptic and suprachiasmatic nuclei, brain regions involved in the regulation of body temperature and circadian rhythm. These findings suggest that hypothermia and disruption of the diurnal rhythm of body temperature can be reversed by restoration of adequate thiamine levels and are related to biochemical and physiological disturbances rather than gross structural changes.
- Baum, R.A. and Iber, F.L. (1984). Thiamin-the interaction of aging, alcoholism, and malabsorption in various populations. World Rev. Nutr. Diet 44:85–116.
- Butterworth, R.F. and Besnard, A.M. (1990). Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease. Metab. Brain Dis. 5:179–184.
- Clark, W.G. and Clark, L.D. (1980). Changes in body temperature after administration of acetylcholine, histamine, morphine, prostaglandins and related agents. Neurosci. Biobehav. Rev. 4:175–240. CrossRef
- Crespi, F. and Jouvet, M. (1982). Sleep and indolamine alterations induced by thiamine deficiency. Brain Res. 248:275–283. CrossRef
- Donnan, G.A. and Seeman, E. (1980). Coma and hypothermia in Wernicke's encephalopathy. Aust. N.Z. J. Med. 10:438–439.
- Diamond, P. and LeBlanc, J. (1987). Role of autonomic nervous system in postprandial thermogenesis in dogs. Am. J. Physiol. 252:E719–726.
- Fishbeck, K.H. and Simon, R.P. (1981). Neurological manifestations of accidental hypothermia. Ann. Neurol. 10:384–387.
- Gallaher, E.J., Enger, D.A. and Swen, J.W. (1985). Automated remote temperature measurement in small animals using a telemetry-microcomputer interface. Computer Biological Medicine 15:103–110. CrossRef
- Geny, C., Pradat, P.F., Yulis, J., Walter, S., Cesaro, D., and Degos, J.D. (1992). Hypothermia, Wernicke encephalopathy and multiple sclerosis. Acta Neurologica Scandinavia 86:632–634.
- Gibson, G.E., Sheu, K.-F.R., Baker, A.C., Carlson, K.C., Harding, D., Perrino, P. and Blass, J.P. (1988). Reduced activities of thiamine-dependent enzymes in the brains and peripheral tissues of Alzheimer patients. Arch. Neurol. 45:836–840.
- Gordon, C.J. (1990). Thermal biology of the laboratory rat. Physiology and Behavior, 47:963–991. CrossRef
- Gordon, C.J. (1993). Temperature Regulation in Laboratory Rodents. Cambridge Univ. Press, New York, pp. 111–112.
- Green, M.D., Cox, B., and Lomax, P. (1976). Histamine H1-and H2-receptors in the central thermoregulatory pathway of the rat. J. Neurosci. Res. 1:353–359.
- Hakim, A.M. (1984). The induction and reversibility of cerebral acidosis in thiamine deficiency. Ann. Neurol. 16:673–679.
- Hakim, A.M. and Pappius, H.M. (1983). Sequence of metabolic, clinical, and histological events in experimental thiamine deficiency. Ann. Neurol. 13:365–375.
- Harper, C.G. (1979). Wernicke's encephalopathy: A more common disease than realized. J. Neurol. Neurosurg. Psychiat. 42:226–231.
- Harper, C.G., Giles, M.I, and Finlay-Jones, R. (1986). Clinical signs in the Wernicke-Korsakoff complex—a retrospective analysis of 131 cases diagnosed at autopsy. J. Neurol. Neurosurg. Psychiat. 49:341–345.
- Harper, C.G., Gold, J., Rodriguez, M., and Perdices, M. (1989). The prevalence of the Wernicke-Korsakoff syndrome in Sydney, Australia: A prospective necropsy study. J. Neurol. Neurosurg. Psychiat. 52:282–285.
- Jernigan, T.L., Schafer, K., Butters, N., and Cermak, L.S. (1991). Magnetic resonance imaging of alcoholic Korsakoff patients. Neuropsychopharmacol. 4:175–186.
- Kearsley, J.H. and Musso, A.F. (1980). Hypothermia and coma in the Wernicke-Korsakoff syndrome. Med. J. Aust. 2:504–506.
- Langlais, P.J., Mandel, R.J., and Mair, R.G. (1992). Diencephalic lesions, learning impairments, and intact retrograde memory following acute thiamine deficiency in the rat. Behav. Brain Res. 48:177–185.
- Langlais, P.J., Zhang, S.X., Weilersbacher, G., Hough, L.B., and Barke, K.E. (1994). Histamine-mediated neuronal death in a rat model of Wernicke's encephalopathy. J. Neurosci. Res. 38:565–574.
- LeRoch, K.L., Riche, D., and Sara, S. (1987). Persistence of habituation deficits after neurological recovery from severe thiamine deficiency. Behav. Brain Res. 26:37–46. CrossRef
- Liang, C.C. (1975). Metabolic changes in rats during developing thiamine deficiency. Biochem. J. 146:739–740.
- Lipton, J.M., Dwyer, P.E., and Fossler, D.E. (1974). Effects of brainstem lesions on temperature regulation in hot and cold environments. Am. J. Physiol. 226:356–365.
- Lipton, J.M., Payne, H., Garza, H.R., and Rosenberg, R.N. (1978). Thermolability in Wernicke's encephalopathy. Arch. Neurol. 35:750–753.
- Mann, M.W., and Degos, J.D. (1987). L'hypothermie dans l'encephalopathie de Wernicke. Rev. Neurol. 143:684–686.
- Martin, P.R., Higa, S., Burns, S., Tamarkin, L., Ebert, M.H., and Markey, S.P. (1984). Decreased 6-hydroxymelatonin excretion in Korsakoff's psychosis. Neurol. 34:966–968.
- Martin, P.R., Loewenstein, R.J., Kaye, W.H., Ebert, M.H., Weingartner, H., and Gillin, J.C. (1986). Sleep EEG in Korsakoff's psychosis and Alzheimer's disease. Neurol. 36:411–4.
- Mochizuki, T., Yamatodani, A., Okakura, K., Horii, A., Inagaki, N., and Wada, H. (1992). Circadian rhythm of histamine release from the hypothalamus of freelymoving rats. Physiol. and Behav. 51:391–394. CrossRef
- Onodera, K., Shinoda, H., and Watanabe, T. (1990). Effects of thiamine administration on hypothermia and hypothalamic histamine levels in dietary-induced thiamine deficient rats. Japan J. Pharmacol. 54:339–343.
- O'Rourke, N.P., Bunker, V.W., Thomas, A.J., Finglas, P.M., Bailey, A.L., and Clayton, B.E. (1990). Thiamine status of healthy and institutionalized elderly subjects: analysis of dietary intake and biochemical indices. Age and Aging 19:325–329.
- Osborne, A.R. and Refinetti, R. (1995). Effects of hypothalamic lesions on the body temperature rhythm of the golden hamster. Neuroreport 6:2187–92.
- Parker, W.D., Haas, R., Stumpf, D.A., Parks, J., Eguren, L.A. and Jackson, C. (1984). Brain mitochrondrial metabolism in experimental thiamine deficiency. Neurology 34:1477–1481.
- Philip, G. and Smith, J.F. (1973). Hypothermia and Wernicke's Encephalopathy. Lancet ii:122–124. CrossRef
- Plaitakis, A., Nicklas, W.J., and Berl, S. (1978). Thiamine deficiency: Selective impairment of the cerebellar serotonergic system. Neurol. 28:691–698.
- Plaitakis A, Berl., S., and Tamir, H. (1981). Thiamine deficiency: effect on serotonin binding protein in rat hypothalamus. Brain Research 217:416–419. CrossRef
- Schwenk, J., Gosztonyi, A., Thierauf, P., Iglesias, J., and Langer, E. (1990). Wernicke's encephalopathy in two patients with acquired immunodeficiency syndrome. J. Neurol. 237:445–447. CrossRef
- Sharp, F.R., Bolger, E., and Evans, K. (1982). Thiamine deficiency limits glucose utilization and glial proliferation in brain lesions of symptomatic rats. J. Cereb. Blood Flow Metab. 2:203–207.
- Smith, D.K., Ovesen, L., Chu, R., Sackel, S., and Howard, L. (1983). Hypothermia in a patient with Anorexia Nervosa. Metabolism 2:1151–1154. CrossRef
- Torvik, A., Lindboe, C.F., and Rogde, S. (1982). Brain lesions in alcoholics: A neuropathological study with clinical correlations. J. Neurol. Sci. 56:233–248. CrossRef
- Troncoso, J.C., Johnston, M.V., Hess, K.M., Griffin, J.W., and Price, D.L. (1981). Model of Wernicke's encephalopathy. Arch. Neurol. 38:350–354.
- Tuomisto, L. (1991). Involvement of histamine in circadian and other rhythms. In: (T. Watanabe and H. Wada, eds.) Histaminergic Neurons: Morphology and Function. CRC Press, Boca Raton, pp. 283–295
- Turek, F.W. (1985). Circadian neural rhythms in mammals. Ann. Rev. Physiol. 47:49–64. CrossRef
- Victor, M., Adams, R.D., and Collins, G.H. (1989). The Wernicke-Korsakoff Syndrome and Related Neurologic Disorders Due to Alcoholism and Malnutrition. F.A Davis, Philadelphia. pp.39–52
- Vortmeyer, A.O., and Colmant, H.J. (1988). Differentiation between brain lesions in experimental thiamine deficiency. Virchows Archive A Pathol. Anat. 414:61–67.
- Wada, H., Watanabe, T., Yamatodani, A., Maeyama, K., Itoi, K., Cacaberos, L. et al. (1985). Physiological functions of histamine in the brain. In: (C.R. Ganellin and J.C. Schwartz, eds.) Advances in Biosciences, Vol. 51, Frontiers in Histamine Research, pp. 225–235, Pergamon Press, Oxford.
- Wallis, W.E., Willoughby, E., and Baker, P. (1978). Coma in the Wernicke-Korsakoff syndrome. Lancet 2:400–401. CrossRef
- Watanabe, I. (1978). Pyrithiamine-induced acute thiamine-deficient encephalopathy in the mouse. Exp. Molec. Pathol. 28:381–394. CrossRef
- Thiamine Deficiency-Induced Disruptions in the Diurnal Rhythm and Regulation of Body Temperature in the Rat
Metabolic Brain Disease
Volume 13, Issue 3 , pp 225-239
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers-Plenum Publishers
- Additional Links
- Thiamine deficiency
- diurnal rhythm
- body temperature
- hypothalamic nuclei
- Industry Sectors