International Urology and Nephrology

, Volume 34, Issue 2, pp 245–250

Predictive pathological factors of lymph nodes involvement in the squamous cell carcinoma of the penis


  • Vincenzo Ficarra
    • Department of UrologyUniversity of Verona
  • Guido Martignoni
    • Department of PathologyUniversity of Verona
  • Nicola Maffei
    • Department of UrologyUniversity of Verona
  • Maria Angela Cerruto
    • Department of UrologyUniversity of Verona
  • Giacomo Novara
    • Department of UrologyUniversity of Verona
  • Stefano Cavalleri
    • Department of UrologyUniversity of Verona
  • Walter Artibani
    • Department of UrologyUniversity of Verona

DOI: 10.1023/A:1023243102230

Cite this article as:
Ficarra, V., Martignoni, G., Maffei, N. et al. Int Urol Nephrol (2002) 34: 245. doi:10.1023/A:1023243102230


Objectives:To evaluate the predictive role ofprimary tumor histopathological features inpredicting inguinal lymph nodes involvement inpatients with penile squamous cell carcinoma.Material and methods:We retrospectivelyanalysed pathological records from 30consecutive patients who underwent penectomyfor invasive squamous cell carcinoma of thepenis. All histological specimens were reviewedby the same pathologist. We considered thefollowing histological parameters: histologicalgrading, growth pattern, deph invasion, tumourthickness, nuclear grading, poorlydifferentiated cancer rate, vascular andlymphatic embolization, eosinophilic andmononuclear infiltration and pathologicalstage.Results:Lymph nodes involvement occurred in 5patients who underwent `early' lymphadenectomyand in other 4 ones during oncologicalsurveillance. Lymph nodes metastasis resultedsignificantly correlated with histologicalgrading (p = 0.005), lymphatic (p = 0.005) andvenous (p = 0.02) embolization, corporacavernosa (p = 0.03) and urethra (p = 0.03)infiltration. Histological grading andlymphatic embolization were independentpredictive variables of lymph nodes involvement(p = 0.02).Conclusions:The histological grading andlymphatic embolization have to be considered asimportant parameters to select patients withpenile squamous cell carcinoma to undergo an`early' lymphadenectomy.

Penile squamous cell carcinomaHistopathological featuresLymph nodes involvementInguinal lymphadenectomy

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© Kluwer Academic Publishers 2002