International Urology and Nephrology

, Volume 34, Issue 2, pp 245-250

First online:

Predictive pathological factors of lymph nodes involvement in the squamous cell carcinoma of the penis

  • Vincenzo FicarraAffiliated withDepartment of Urology, University of Verona
  • , Guido MartignoniAffiliated withDepartment of Pathology, University of Verona
  • , Nicola MaffeiAffiliated withDepartment of Urology, University of Verona
  • , Maria Angela CerrutoAffiliated withDepartment of Urology, University of Verona
  • , Giacomo NovaraAffiliated withDepartment of Urology, University of Verona
  • , Stefano CavalleriAffiliated withDepartment of Urology, University of Verona
  • , Walter ArtibaniAffiliated withDepartment of Urology, University of Verona

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Objectives:To evaluate the predictive role ofprimary tumor histopathological features inpredicting inguinal lymph nodes involvement inpatients with penile squamous cell carcinoma.Material and methods:We retrospectivelyanalysed pathological records from 30consecutive patients who underwent penectomyfor invasive squamous cell carcinoma of thepenis. All histological specimens were reviewedby the same pathologist. We considered thefollowing histological parameters: histologicalgrading, growth pattern, deph invasion, tumourthickness, nuclear grading, poorlydifferentiated cancer rate, vascular andlymphatic embolization, eosinophilic andmononuclear infiltration and pathologicalstage.Results:Lymph nodes involvement occurred in 5patients who underwent `early' lymphadenectomyand in other 4 ones during oncologicalsurveillance. Lymph nodes metastasis resultedsignificantly correlated with histologicalgrading (p = 0.005), lymphatic (p = 0.005) andvenous (p = 0.02) embolization, corporacavernosa (p = 0.03) and urethra (p = 0.03)infiltration. Histological grading andlymphatic embolization were independentpredictive variables of lymph nodes involvement(p = 0.02).Conclusions:The histological grading andlymphatic embolization have to be considered asimportant parameters to select patients withpenile squamous cell carcinoma to undergo an`early' lymphadenectomy.

Penile squamous cell carcinoma Histopathological features Lymph nodes involvement Inguinal lymphadenectomy