Journal of Applied Phycology

, Volume 15, Issue 1, pp 87–90

Antiangiogenic properties of a sulfated galactan isolated from a marine green alga, Codium cylindricum

  • Kiminori Matsubara
  • Masaharu Mori
  • Hiroaki Matsumoto
  • Kanji Hori
  • Keisuke Miyazawa
Article

DOI: 10.1023/A:1022958222915

Cite this article as:
Matsubara, K., Mori, M., Matsumoto, H. et al. Journal of Applied Phycology (2003) 15: 87. doi:10.1023/A:1022958222915

Abstract

An anticoagulant sulfated galactan isolated from the marine green alga, Codium cylindricum, was shown to have antiangiogeinic activity. This galactan suppressed microvessel formation in an ex vivo serum-free matrix culture model using rat aortic ring. It also inhibited human umbilical vein endothelial cells (HUVEC) tube formation on reconstituted basement membrane gel. These results show the value of algal sulfated galactans in the design of antiangiogenic agents.

AngiogenesisCodium cylindricumGreen algaInhibitionSulfated galactan

Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Kiminori Matsubara
    • 1
  • Masaharu Mori
    • 2
  • Hiroaki Matsumoto
    • 3
  • Kanji Hori
    • 4
  • Keisuke Miyazawa
    • 4
  1. 1.Department of Nutritional Science, Faculty of Health and Welfare ScienceOkayama Prefectural UniversitySojaJapan
  2. 2.Department of Nursing, Faculty of Health and Welfare ScienceOkayama Prefectural UniversitySojaJapan
  3. 3.Department of Nutritional Science, Faculty of Health and Welfare ScienceOkayama Prefectural UniversitySojaJapan
  4. 4.Graduate School of Biosphere SciencesHiroshima UniversityHigashi-HiroshimaJapan