Journal of Applied Phycology

, Volume 15, Issue 1, pp 87–90

Antiangiogenic properties of a sulfated galactan isolated from a marine green alga, Codium cylindricum

Authors

  • Kiminori Matsubara
    • Department of Nutritional Science, Faculty of Health and Welfare ScienceOkayama Prefectural University
  • Masaharu Mori
    • Department of Nursing, Faculty of Health and Welfare ScienceOkayama Prefectural University
  • Hiroaki Matsumoto
    • Department of Nutritional Science, Faculty of Health and Welfare ScienceOkayama Prefectural University
  • Kanji Hori
    • Graduate School of Biosphere SciencesHiroshima University
  • Keisuke Miyazawa
    • Graduate School of Biosphere SciencesHiroshima University
Article

DOI: 10.1023/A:1022958222915

Cite this article as:
Matsubara, K., Mori, M., Matsumoto, H. et al. Journal of Applied Phycology (2003) 15: 87. doi:10.1023/A:1022958222915

Abstract

An anticoagulant sulfated galactan isolated from the marine green alga, Codium cylindricum, was shown to have antiangiogeinic activity. This galactan suppressed microvessel formation in an ex vivo serum-free matrix culture model using rat aortic ring. It also inhibited human umbilical vein endothelial cells (HUVEC) tube formation on reconstituted basement membrane gel. These results show the value of algal sulfated galactans in the design of antiangiogenic agents.

AngiogenesisCodium cylindricumGreen algaInhibitionSulfated galactan

Copyright information

© Kluwer Academic Publishers 2003