Article

Journal of Applied Phycology

, Volume 15, Issue 1, pp 87-90

First online:

Antiangiogenic properties of a sulfated galactan isolated from a marine green alga, Codium cylindricum

  • Kiminori MatsubaraAffiliated withDepartment of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University
  • , Masaharu MoriAffiliated withDepartment of Nursing, Faculty of Health and Welfare Science, Okayama Prefectural University
  • , Hiroaki MatsumotoAffiliated withDepartment of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University
  • , Kanji HoriAffiliated withGraduate School of Biosphere Sciences, Hiroshima University
  • , Keisuke MiyazawaAffiliated withGraduate School of Biosphere Sciences, Hiroshima University

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Abstract

An anticoagulant sulfated galactan isolated from the marine green alga, Codium cylindricum, was shown to have antiangiogeinic activity. This galactan suppressed microvessel formation in an ex vivo serum-free matrix culture model using rat aortic ring. It also inhibited human umbilical vein endothelial cells (HUVEC) tube formation on reconstituted basement membrane gel. These results show the value of algal sulfated galactans in the design of antiangiogenic agents.

Angiogenesis Codium cylindricum Green alga Inhibition Sulfated galactan