Annals of Operations Research

, Volume 119, Issue 1, pp 261–284

Using an Integer Programming Model to Determine the Price of Combination Vaccines for Childhood Immunization

  • Edward C. Sewell
  • Sheldon H. Jacobson

DOI: 10.1023/A:1022955111568

Cite this article as:
Sewell, E.C. & Jacobson, S.H. Annals of Operations Research (2003) 119: 261. doi:10.1023/A:1022955111568


The Recommended Childhood Immunization Schedule has become sufficiently crowded that the prospect of adding additional vaccines to this schedule may not be well received by either health-care providers or parents/guardians. This has encouraged vaccine manufacturers to develop combination vaccines that can permit new vaccines to be added to the schedule without requiring children to be exposed to an unacceptable number of injections during a single clinic visit. This paper develops an integer programming model to assess the economic premium that exists in having combination vaccines available. The results of this study suggest that combination vaccines provide a cost effective alternative to individual vaccines and that further developments and innovations in this area by vaccine manufacturers can provide significant economic and societal benefits.

integer programmingcombination vaccinespediatric immunizationreverse engineeringeconomic analysis

Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Edward C. Sewell
    • 1
  • Sheldon H. Jacobson
    • 2
  1. 1.Department of Mathematics and StatisticsSouthern Illinois University EdwardsvilleEdwardsvilleUSA
  2. 2.Department of Mechanical and Industrial EngineeringUniversity of Illinois at Urbana-ChampaignUrbanaUSA