Digestive Diseases and Sciences

, Volume 48, Issue 4, pp 750–754

Granulocyte Adsorptive Apheresis for Pediatric Patients with Ulcerative Colitis

  • Takeshi Tomomasa
  • Akio Kobayashi
  • Hiroaki Kaneko
  • Sasaki Mika
  • Shun-ichi Maisawa
  • Yoshie Chino
  • Hohkibara Syou
  • Atsushi Yoden
  • Jyunko Fujino
  • Makoto Tanikawa
  • Takafumi Yamashita
  • Shigeru Kimura
  • Maiko Kanoh
  • Koji Sawada
  • Akihiro Morikawa
Article

DOI: 10.1023/A:1022892927121

Cite this article as:
Tomomasa, T., Kobayashi, A., Kaneko, H. et al. Dig Dis Sci (2003) 48: 750. doi:10.1023/A:1022892927121

Abstract

Granulocytapheresis (GCAP) has produced efficacy in adult patients with ulcerative colitis (UC) by adsorbing activated granulocytes and monocytes/macrophages. We retrospectively investigated efficacy and safety of GCAP in pediatric patients with active UC. Twelve steroid-refractory children (12.2±3.1 years old) were treated with GCAP, one session/week for 5–10 consecutive weeks. In 8 patients, clinical symptoms improved after two GCAP sessions. Normal body temperature, stool frequency, and disappearance of blood in stool were seen after 24.3±11.5 days. The endoscopic grade improved from 2.6±0.3 to 0.4±0.2. One patient who initially responded, developed bloody diarrhea later and 2 cases remained unchanged. The dose of steroid was tapered during GCAP therapy by 50%. No serious adverse effects were noted. Four of 8 cases relapsed 3.5 ± 2.2 months after the last GCAP while on maintenance therapy, the other 4 were in remission up to 22.8±18.1 months. In conclusion, GCAP appears to be effective and well tolerated in children with steroid-refractory UC.

apheresisulcerative colitispediatric patientsprednisolonesteroid

Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  • Takeshi Tomomasa
    • 1
  • Akio Kobayashi
    • 2
  • Hiroaki Kaneko
    • 3
  • Sasaki Mika
    • 4
  • Shun-ichi Maisawa
    • 5
  • Yoshie Chino
    • 6
  • Hohkibara Syou
    • 7
  • Atsushi Yoden
    • 8
  • Jyunko Fujino
    • 9
  • Makoto Tanikawa
  • Takafumi Yamashita
  • Shigeru Kimura
  • Maiko Kanoh
  • Koji Sawada
  • Akihiro Morikawa
    • 3
  1. 1.Department of PediatricsGunma University Faculty of MedicineGunmaJapan
  2. 2.Showa University Toyosu HospitalJapan
  3. 3.Department of PediatricsGunma University Faculty of MedicineJapan
  4. 4.Iwate Medical SchoolJapan
  5. 5.Morioka Children's HospitalJapan
  6. 6.National Center for Child Health and DevelopmentJapan
  7. 7.Nagano Children's HospitalJapan
  8. 8.Department of Pediatric SurgeryOsaka Medical CollegeJapan
  9. 9.Department of Internal MedicineDokkyo University Koshigaya HospitalJapan