Journal of Nanoparticle Research

, Volume 4, Issue 6, pp 535–540

Microstructure and Chemical States of Hydroxyapatite/silk Fibroin Nanocomposites Synthesized via A Wet-mechanochemical Route


DOI: 10.1023/A:1022841507932

Cite this article as:
Wang, L., Nemoto, R. & Senna, M. Journal of Nanoparticle Research (2002) 4: 535. doi:10.1023/A:1022841507932


Hydroxyapaptite (HAp)/silk fibroin (SF) nanocomposites were prepared via a wet-mechanochemical route at room temperature. The results reveal that the inorganic phase in the composites is carbonate-substituted HAp containing 2.9–3.1 wt% of carbonate ions. The primary HAp crystals are rod-like in shape with a typical size of 20–30 nm in length and 8–10 nm in width, and lattice parameters a = 9.423 Å, c = 6.888 Å. The self-assembled HAp crystals along their c-axes aggregate into bundles, which are connected with SF fibrils. Consequently, a three-dimensional porous network is formed in the composite, which is beneficial to inducing new bone formation in practical implantation.

hydroxyapatitesilk fibroinporous nanocompositemicrostructurechemical statebone substitute

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  1. 1.Department of Applied Chemistry, Faculty of Science and TechnologyKeio UniversityYokohamaJapan