Journal of Structural and Functional Genomics

, Volume 3, Issue 1, pp 95–110

The 2R hypothesis and the human genome sequence

  • Karsten Hokamp
  • Aoife McLysaght
  • Kenneth H. Wolfe

DOI: 10.1023/A:1022661917301

Cite this article as:
Hokamp, K., McLysaght, A. & Wolfe, K.H. J Struct Func Genom (2003) 3: 95. doi:10.1023/A:1022661917301


One theory formalised in 1970 proposes that the complexity of vertebrate genomes originated by means of genome duplication at the base of the vertebrate lineage. Since then, the theory has remained both popular and controversial. Here we review the theory, and present preliminary results from our analysis of duplications in the draft human genome sequence. We find evidence for extensive duplication of parts of the genome. We also question the validity of the 'parsimony test' that has been used in other analyses.

human genomeparalogonpolyploidy2R hypothesis

Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Karsten Hokamp
  • Aoife McLysaght
  • Kenneth H. Wolfe
    • 1
  1. 1.Department of Genetics, Smurfit InstituteUniversity of Dublin, Trinity CollegeDublin 2Ireland