Numerous groups of chromosomal regional paralogies strongly indicate two genome doublings at the root of the vertebrates

  • Lars-Gustav Lundin
  • Dan Larhammar
  • Finn Hallböök
Article

DOI: 10.1023/A:1022600813840

Cite this article as:
Lundin, LG., Larhammar, D. & Hallböök, F. J Struct Func Genom (2003) 3: 53. doi:10.1023/A:1022600813840

Abstract

The appearance of the vertebrates demarcates some of the most far-reaching changes of structure and function seen during the evolution of the metazoans. These drastic changes of body plan and expansion of the central nervous system among other organs coincide with increased gene numbers. The presence of several groups of paralogous chromosomal regions in the human genome is a reflection of this increase. The simplest explanation for the existence of these paralogies would be two genome doublings with subsequent silencing of many genes. It is argued that gene localization data and the delineation of paralogous chromosomal regions give more reliable information about these types of events than dendrograms of gene families as gene relationships are often obscured by uneven replacement rates as well as other factors. Furthermore, the topographical relations of some paralogy groups are discussed.

conservaton of chromosomal regions genome doubling paralogous chromosomal regions vertebrate evolution 

Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Lars-Gustav Lundin
    • 1
  • Dan Larhammar
    • 1
  • Finn Hallböök
    • 1
  1. 1.Department of Neuroscience, BMCUppsala UniversityUppsalaSweden