Clinical & Experimental Metastasis

, Volume 20, Issue 1, pp 59–68

Overexpression and functional alterations of the EphA2 tyrosine kinase in cancer

  • Michael S. Kinch
  • Kelly Carles-Kinch

DOI: 10.1023/A:1022546620495

Cite this article as:
Kinch, M.S. & Carles-Kinch, K. Clin Exp Metastasis (2003) 20: 59. doi:10.1023/A:1022546620495


Cancer is a disease of aberrant signal transduction. The expression and function of intracellular signaling pathways are frequently subverted as cells progress towards a metastatic phenotype. In particular, tyrosine kinases initiate powerful signals that govern many different aspects of cell behavior. In Recent studies have demonstrated that the EphA2 receptor tyrosine kinase is frequently overexpressed and functionally altered in aggressive tumor cells, and that these changes promote metastatic character. Herein, we provide an overview of our current understanding of EphA2, with emphasis upon the differential regulation of EphA2 expression and function. We also show that differential EphA2 expression and function may provide a unique opportunity for selective therapeutic targeting of EphA2 in metastatic disease.

EphA2ephrinmetastasismonoclonal antibodyoncogenetyrosine kinase

Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Michael S. Kinch
    • 1
  • Kelly Carles-Kinch
    • 1
  1. 1.MedImmune, Inc.GaithersburgUSA