Journal of Bioenergetics and Biomembranes

, Volume 29, Issue 4, pp 365–377

Mitochondrial Biogenesis in the Liver during Development and Oncogenesis

  • José M. Cuezva
  • Luciana K. Ostronoff
  • Javier Ricart
  • Miguel López de Heredia
  • Carlo M. Di Liegro
  • José M. Izquierdo
Article

DOI: 10.1023/A:1022450831360

Cite this article as:
Cuezva, J.M., Ostronoff, L.K., Ricart, J. et al. J Bioenerg Biomembr (1997) 29: 365. doi:10.1023/A:1022450831360

Abstract

The analysis of the expression of oxidative phosphorylation genes in the liver during development reveals the existence of two biological programs involved in the biogenesis of mitochondria. Differentiation is a short-term program of biogenesis that is controlled at post-transcriptional levels of gene expression and is responsible for the rapid changes in the bioenergetic phenotype of mitochondria. In contrast, proliferation is a long-term program controlled both at the transcriptional and post-transcriptional levels of gene expression and is responsible for the increase in mitochondrial mass in the hepatocyte. Recently, a specific subcellular structure involved in the localization and control of the translation of the mRNA encoding the β-catalytic subunit of the H+-ATP synthase (β-mRNA) has been identified. It is suggested that this structure plays a prominent role in the control of mitochondrial biogenesis at post-transcriptional levels. The fetal liver has many phenotypic manifestations in common with highly glycolytic tumor cells. In addition, both have a low mitochondrial content despite a paradoxical increase in the cellular representation of oxidative phosphorylation transcripts. Based on the paradigm provided by the fetal liver we hypothesize that the aberrant mitochondrial phenotype of fast-growing hepatomas represents a reversion to a fetal program of expression of oxidative phosphorylation genes by the activation, or increased expression, of an inhibitor of β-mRNA translation.

Mitochondrial biogenesis differentiation of mitochondria proliferation of mitochondria liver oxidative phosphorylation genes regulation gene expression development oncogenesis mitochondrial DNA mRNA localization 

Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • José M. Cuezva
    • 1
  • Luciana K. Ostronoff
    • 1
  • Javier Ricart
    • 1
  • Miguel López de Heredia
    • 1
  • Carlo M. Di Liegro
    • 1
  • José M. Izquierdo
    • 1
  1. 1.Departamento de Biología Molecular, Centro de Biología Molecular “Severo Ochoa,” Universidad Autónoma de Madrid, Consejo Superior de Investigaciones CientíficasUniversidad Autónoma de MadridMadridSpain